رسالة جامعية
Alterações centrais e periféricas relacionadas ao balanço energético de ratos submetidos ao exercício resistido e expostos ao decanoato de nandrolona ; Central and peripheral changes on energy balance in rats submitted to resistance training and exposed to nandrolone decanoate
| العنوان: | Alterações centrais e periféricas relacionadas ao balanço energético de ratos submetidos ao exercício resistido e expostos ao decanoato de nandrolona ; Central and peripheral changes on energy balance in rats submitted to resistance training and exposed to nandrolone decanoate |
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| المؤلفون: | Pozzi, Renan UNIFESP |
| المساهمون: | D'Almeida, Vania UNIFESP, Universidade Federal de São Paulo (UNIFESP), http://lattes.cnpq.br/0724678991395028Test, http://lattes.cnpq.br/7220411418339421Test |
| بيانات النشر: | Universidade Federal de São Paulo (UNIFESP) |
| سنة النشر: | 2016 |
| المجموعة: | Universidade Federal de São Paulo (UNIFESP): Repositório Institucional |
| مصطلحات موضوعية: | Anabolic androgenic steroids, Resistance exercise, Energy balance, Rats, Leptin and orexin, Treinamento resistido, Esteróides anabólicos androgênicos, Balanço energético, Ratos, Leptina e orexina |
| جغرافية الموضوع: | São Paulo |
| الوصف: | Resistance training (REx) and chronic supraphysiological use of anabolic androgenic steroids (AAS) modify neuroendocrine responses. However, the association of both is still unclear. Our aim was to evaluate the effects of nandrolone decanoate (DECA) associated with REx on central and peripheral hormones and neuropeptides related to energy balance. Experimental protocol was performed for 8wk as follow: control (C) group: exposed to vehicle 3x/wk; trained (T) group: REx 5x/wk and vehicle 3x/wk; decanoate (D) group: exposed to DECA (s.a. 5mg/kg) 3x/wk and; TD group: submitted to REx 5x/wk and DECA (s.a. 5mg/kg) 3x/wk. Efficiency training was confirmed by cross sectional area analysis of the gastrocnemius muscle, which was higher in T and TD groups than C and D groups. In TD group there was no body mass gain compared to C group, moreover, there was a reduction of total fat in T and TD compared to C group. We observed an increase of prepro-orexin mRNA expression in T and TD compared to C group and the absence of changes in NPY, AGRP, POMC, CART, ghrelin receptor, leptin receptor, orexin-A receptor, androgenic receptor and ?-estrogen receptor mRNA hypothalamic expression. There was a decreased of leptin expression in fat tissue in T and TD compared to C group and, a reduction of androgrenic receptor in D group and increase in orexin-2-receptor in adrenal gland compared to C group. We also observed a reduction on plasma leptin levels in D, T and TD compared to C group and an increase on plasma orexin-A levels in D compared to C and T groups, however, there was no differences for plasmatic levels of ghrelin, insulin, MCH, NPY, corticosterone and testosterone. Our data showed resistance training plays a central and peripheral role on energy balance while DECA changed only peripheral components. In addition, the results indicate that leptin and orexin were the most affected components by DECA and resistance training. ; O treinamento resistido (REx) e o uso crônico suprafarmacológico de esteróides anabólicos androgênicos ... |
| نوع الوثيقة: | doctoral or postdoctoral thesis |
| وصف الملف: | 121 f.; application/pdf |
| اللغة: | Portuguese |
| العلاقة: | https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=3724847Test; POZZI, Renan. Alterações centrais e periféricas relacionadas ao balanço energético de ratos submetidos ao exercício resistido e expostos ao decanoato de nandrolona. 2016. 121 f. Tese (Doutorado em Psicobiologia) - Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, 2016.; http://repositorio.unifesp.br/handle/11600/46217Test; Renan Pozzi - PDF A.pdf |
| الإتاحة: | http://repositorio.unifesp.br/handle/11600/46217Test https://sucupira.capes.gov.br/sucupira/public/consultas/coleta/trabalhoConclusao/viewTrabalhoConclusao.jsf?popup=true&id_trabalho=3724847Test |
| حقوق: | Acesso aberto |
| رقم الانضمام: | edsbas.59A0452D |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |