مؤتمر
Prenatal exposure to lipophilic endocrine-disrupting chemicals and liver injury in children using chemical mixture approaches
| العنوان: | Prenatal exposure to lipophilic endocrine-disrupting chemicals and liver injury in children using chemical mixture approaches |
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| المؤلفون: | Midya, Vishal, Colicino, Elena, Conti, David V, Berhane, Kiros T, Garcia, Erika, Stratakis, Nikos, Andrušaitytė, Sandra, Basagaña, Xavier, Gražulevičienė, Regina, Haug, Line Småstuen, Heude, Barbara, Papadopoulou, Eleni, McEachan, Rosemary R. C, Roumeliotaki, Theano, Slama, Rémy, Urquiza, Jose, Vafeiadi, Marina, Varo, Nerea, Vos, Miriam B, Wright, John, Casas, Maribe, McConnell, Rob, Vrijheid, Martine, Chatzi, Leda, Valvi, Damaskini |
| سنة النشر: | 2021 |
| المجموعة: | Vytautas Magnus University e-Publication Repository (VMU ePub) / Vytauto Didžiojo universitetas: e. publikacijų talpykla (VDU ePub) |
| مصطلحات موضوعية: | Chemical exposures, Endocrine disrupting chemicals, Mixtures analysis, Environmental epidemiology, Konferencijų tezės nerecenzuojamuose leidiniuose / Conference theses in non-peer-reviewed publications (T2), Ekologija ir aplinkotyra / Ecology and environmental sciences (N012) |
| جغرافية الموضوع: | US |
| الوصف: | BACKGROUND AND AIM: Exposure to Endocrine Disrupting Chemicals (EDC) may increase liver injury, but few studies have examined these associations in children and most focused on a single chemical group. We evaluated the associations between a wide range of prenatal EDC exposures and child liver injury. METHODS: We studied 1108 healthy children from the Human Early-Life Exposome (HELIX) project, a collaborative network of six established longitudinal population-based birth cohort studies in Europe. Thirty lipophilic EDCs (including 3 organochlorine pesticides, 5 polychlorinated-biphenyl, 2 polybrominated-diphenyl-ethers [PBDEs], 5 high molecular weight phthalates (HMWP), 5 low molecular weight phthalates, 6 phenols and 4 organophosphate pesticides) were measured in maternal pregnancy blood or urine. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT) and cytokeratin 18 (CK18) were measured in child serum at follow-up between age 6-11 years. Liver injury was defined as having any liver enzyme (ALT, AST or GGT) above the 90th percentile. We used Bayesian generalized linear mixed regressions (Bglmr) to estimate associations of individual chemicals, Bayesian Weighted Quantile Sum (BWQS) and Bayesian Kernel Machine Regression (BKMR) to assess the overall association of each chemical group with liver injury and CK18, adjusting for confounders. RESULTS:BWQS results indicated that organochlorine pesticides and PBDEs were associated with increased odds of liver injury (OR[95%CI] by chemical mixture quartile increase=1.44[1.23, 1.72] and 1.59[1.37, 1.90], respectively); whereas HMWP were associated with decreased odds of liver injury (OR[95%CI]=0.71[0.59, 0.85]). A quartile increase of PBDEs was positively associated with CK18 (Estimate[95%CI]=5.33 Units/Liter [2.52,8.16]). Bglmr and BKMR showed associations in same direction as the BWQS results. [.] ; Aplinkotyros katedra ; Vytauto Didžiojo universitetas |
| نوع الوثيقة: | conference object |
| وصف الملف: | p. 140-142 |
| اللغة: | English |
| العلاقة: | ISEE 2021: 33rd annual conference of the International Society for Environmental Epidemiology: Promoting environmental health and equity in a shifting climate, August 23-26, 2021, New York, United States : online conference abstract E-book. New York: Columbia University Mailman School of Public Health, 2021; VDU02-000067871; https://hdl.handle.net/20.500.12259/144654Test |
| DOI: | 10.1289/isee.2021.O-TO-109 |
| الإتاحة: | https://doi.org/20.500.12259/144654Test https://hdl.handle.net/20.500.12259/144654Test |
| رقم الانضمام: | edsbas.59653D50 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1289/isee.2021.O-TO-109 |
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