دورية أكاديمية
Ascitic fluid infection in patients with hepatitis B virus-related liver cirrhosis: culture-negative neutrocytic ascites versus spontaneous bacterial peritonitis
| العنوان: | Ascitic fluid infection in patients with hepatitis B virus-related liver cirrhosis: culture-negative neutrocytic ascites versus spontaneous bacterial peritonitis |
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| المساهمون: | Seung Up Kim, Do Young Kim, Chun Kyon Lee, Jun Yong Park, Sun Hye Kim, Hee Man Kim, Eun Hee Choi, Sinyoung Kim, Kwang-Hyub Han, Chae Yoon Chon, Sang Hoon Ahn, Kim, Sin Young, Kim, Hee Man, Park, Jun Yong, Ahn, Sang Hoon, Chon, Chae Yoon, Choi, Eun Hee, Han, Kwang Hyup, Kim, Do Young, Kim, Seung Up |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Ascites/microbiology, Ascites/mortality, Ascites/therapy, Ascitic Fluid/microbiology, Female, Hepatitis B/complications, Hepatitis B/diagnosis, Hepatitis B/mortality, Hepatitis B/therapy, Hospital Mortality, Humans, Kaplan-Meier Estimate, Korea/epidemiology, Liver Cirrhosis/mortality, Liver Cirrhosis/therapy, Liver Cirrhosis/virology, Liver Transplantation, Logistic Models, Male, Middle Aged, Paracentesis, Patient Selection, Peritonitis/microbiology, Peritonitis/mortality, Peritonitis/therapy, Proportional Hazards Models, Risk Assessment, Risk Factors, Severity of Illness Index, Time Factors |
| الوصف: | BACKGROUND AND AIM: Ascitic fluid infection (AFI) consists of culture-negative neutrocytic ascites (CNNA) and spontaneous bacterial peritonitis (SBP). The present study compared the clinical characteristics and prognosis of CNNA and SBP in hepatitis B virus (HBV)-related cirrhotic patients. METHODS: We analyzed 130 consecutive patients hospitalized due to the first episode of AFI between January 1998 and December 2007. RESULTS: The mean age of the patients was 52.3 years (88 men, 42 women). Ninety-three patients (71.5%) had CNNA and 37 patients (28.5%) had SBP; 117 patients (90.0%) died after a median survival period of 6.4 months. Patients with CNNA and SBP survived for a median period of 6.9 months and 5.4 months, respectively (P = 0.417). Patients with SBP showed higher in-hospital mortality than those with CNNA (16.2 vs 4.3%; P = 0.031). Binary logistic regression analysis showed that culture positivity of ascitic fluid (CNNA vs SBP) was the only independent predictor of in-hospital mortality (P = 0.042). In a Cox regression model for the 120 patients (92.3%) who survived the first episode of AFI, only the Child-Pugh score remained significant for survival (P = 0.007), whereas no association was observed for culture positivity of ascitic fluid (CNNA vs SBP) during the first episode of AFI (P = 0.752). CONCLUSIONS: Although in-hospital mortality was higher in patients with SBP than CNNA, the clinical course of the two groups was similar after the first episode of AFI. Thus, liver transplantation should be considered, irrespective of culture positivity of ascitic fluid. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 122~128 |
| اللغة: | unknown |
| تدمد: | 0815-9319 1440-1746 |
| العلاقة: | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY; J01417; OAK-2010-00091; https://ir.ymlib.yonsei.ac.kr/handle/22282913/100491Test; T201000119; JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.25(1) : 122-128, 2010 |
| DOI: | 10.1111/j.1440-1746.2009.05970.x |
| DOI: | 10.1111/j.1440-1746.2009.05970.x/abstract |
| الإتاحة: | https://doi.org/10.1111/j.1440-1746.2009.05970.xTest https://ir.ymlib.yonsei.ac.kr/handle/22282913/100491Test |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ |
| رقم الانضمام: | edsbas.59590E2B |
| قاعدة البيانات: | BASE |
| تدمد: | 08159319 14401746 |
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| DOI: | 10.1111/j.1440-1746.2009.05970.x |