دورية أكاديمية
Candidate mechanisms of acquired resistance to first-line osimertinib in EGFR-mutated advanced non-small cell lung cancer
| العنوان: | Candidate mechanisms of acquired resistance to first-line osimertinib in EGFR-mutated advanced non-small cell lung cancer |
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| المساهمون: | Juliann Chmielecki, Jhanelle E Gray, Ying Cheng, Yuichiro Ohe, Fumio Imamura, Byoung Chul Cho, Meng-Chih Lin, Margarita Majem, Riyaz Shah, Yuri Rukazenkov, Alexander Todd, Aleksandra Markovets, J Carl Barrett, Ryan J Hartmaier, Suresh S Ramalingam, Cho, Byoung Chul |
| بيانات النشر: | Nature Pub. Group |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Carcinoma, Non-Small-Cell Lung* / drug therapy, Non-Small-Cell Lung* / genetics, ErbB Receptors / genetics, Humans, Lung Neoplasms* / drug therapy, Lung Neoplasms* / genetics, Mutation, Protein Kinase Inhibitors / pharmacology, Protein Kinase Inhibitors / therapeutic use |
| الوصف: | Osimertinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), potently and selectively inhibits EGFR-TKI-sensitizing and EGFR T790M resistance mutations. In the Phase III FLAURA study (NCT02296125), first-line osimertinib improved outcomes vs comparator EGFR-TKIs in EGFRm advanced non-small cell lung cancer. This analysis identifies acquired resistance mechanisms to first-line osimertinib. Next-generation sequencing assesses circulating-tumor DNA from paired plasma samples (baseline and disease progression/treatment discontinuation) in patients with baseline EGFRm. No EGFR T790M-mediated acquired resistance are observed; most frequent resistance mechanisms are MET amplification (n = 17; 16%) and EGFR C797S mutations (n = 7; 6%). Future research investigating non-genetic acquired resistance mechanisms is warranted. © 2023. The Author(s). ; open |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2041-1723 |
| العلاقة: | NATURE COMMUNICATIONS; J02293; OAK-2023-01384; https://ir.ymlib.yonsei.ac.kr/handle/22282913/195303Test; T202302907; NATURE COMMUNICATIONS, Vol.14(1) : 1070, 2023-02 |
| DOI: | 10.1038/s41467-023-35961-y |
| الإتاحة: | https://doi.org/10.1038/s41467-023-35961-yTest https://ir.ymlib.yonsei.ac.kr/handle/22282913/195303Test |
| حقوق: | CC BY-NC-ND 2.0 KR |
| رقم الانضمام: | edsbas.59145088 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20411723 |
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| DOI: | 10.1038/s41467-023-35961-y |