التفاصيل البيبلوغرافية
| العنوان: |
Metastatic small cell bladder cancer treated with sequential systemic therapy including pembrolizumab and amrubicin: A case report |
| المؤلفون: |
Mitani, Kazutaka, Tsuboi, Ichiro, Tanaka, Gen, Yosioka, Saori, Yokoyama, Shuhei, Kobayashi, Yusuke, Nakajima, Hirochika, Nagami, Taichi, Ogawa, Kohei, Wada, Koichiro |
| المصدر: |
IJU Case Reports ; volume 7, issue 2, page 127-130 ; ISSN 2577-171X 2577-171X |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2023 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Introduction Small cell bladder cancer is a relatively rare tumor, representing <1% of all bladder tumors. Amrubicin monotherapy is used as second‐line treatment for small cell lung cancer in Japan. Case presentation A 79‐year‐old woman presented with gross hematuria and was diagnosed with small cell bladder cancer (T2 or higher). Neoadjuvant chemotherapy with etoposide and cisplatin resulted in a partial response. Robot‐assisted radical cystectomy was performed, and radical resection was achieved. As we identified metastasis in the pleura 1 year later, we administered carboplatin and etoposide, which resulted in a partial response. Although pembrolizumab was initiated as maintenance therapy, it was not effective. Amrubicin was given as third‐line therapy, and stable disease was achieved without serious adverse effect for 6 months. Conclusion Although there is no established treatment for metastatic small cell bladder cancer, the current case report suggests the effectiveness of amrubicin in this setting. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/iju5.12684 |
| الإتاحة: |
https://doi.org/10.1002/iju5.12684Test |
| حقوق: |
http://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: |
edsbas.58EFFA38 |
| قاعدة البيانات: |
BASE |
