دورية أكاديمية
Smad2 transduces common signals from receptor serinethreonine and tyrosine kinases
| العنوان: | Smad2 transduces common signals from receptor serinethreonine and tyrosine kinases |
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| المؤلفون: | Caestecker, De, Parks, W. T., Frank, C. J., Castagnino, P., Bottaro, D. P., Roberts, Lechleider, R. J. |
| سنة النشر: | 1998 |
| المجموعة: | Zenodo |
| الوصف: | SMAD proteins mediate signals from receptor serine-threonine kinases (RSKs) of the TGF-beta superfamily. We demonstrate here that HGF and EGF, which signal through RTKs, can also mediate SMAD-dependent reporter gene activation and induce rapid phosphorylation of endogenous SMAD proteins by kinase(s) downstream of MEK1. HGF induces phosphorylation and nuclear translocation of epitope-tagged Smad2 and a mutation that blocks TGF-beta signaling also blocks HGF signal transduction. Smad2 may thus act as a common positive effector of TGF-beta- and HGF-induced signals and serve to modulate cross talk between RTK and RSK signaling pathways. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://zenodo.org/record/894806Test; https://doi.org/10.5281/zenodo.894806Test; oai:zenodo.org:894806 |
| DOI: | 10.5281/zenodo.894806 |
| الإتاحة: | https://doi.org/10.5281/zenodo.894806Test https://doi.org/10.5281/zenodo.894805Test https://zenodo.org/record/894806Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.58CF69D5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.5281/zenodo.894806 |
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