دورية أكاديمية
PPARGC1A rs8192678 and NRF1 rs6949152 Polymorphisms Are Associated with Muscle Fiber Composition in Women
| العنوان: | PPARGC1A rs8192678 and NRF1 rs6949152 Polymorphisms Are Associated with Muscle Fiber Composition in Women |
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| المؤلفون: | Yvert, Thomas Paul, Miyamoto-Mikami, Eri, Tobina, Takuro, Shiose, Keisuke, Kakigi, Ryo, Tsuzuki, Takamasa, Takaragawa, Mizuki, Ichinoseki-Sekine, Noriko, Pérez Ruiz, Margarita, Fuku, Noriyuki |
| سنة النشر: | 2020 |
| المجموعة: | Universidad Europea: ABACUS |
| مصطلحات موضوعية: | Genética humana, Mujeres, Fisiología humana, Mujer |
| الوصف: | PPARGC1A rs8192678 G/A (Gly482Ser) and NRF1 rs6949152 A/G polymorphisms have been associated with endurance athlete status, endurance performance phenotypes, and certain health-related markers of different pathologies such as metabolic syndrome, diabetes, and dyslipidemia. We hypothesized that they could be considered interesting candidates for explaining inter-individual variations in muscle fiber composition in humans. We aimed to examine possible associations of these polymorphisms with myosin heavy-chain (MHC) isoforms as markers of muscle fiber compositions in vastus lateralis muscle in a population of 214 healthy Japanese subjects, aged between 19 and 79 years. No significant associations were found in men for any measured variables. In contrast, in women, the PPARGC1A rs8192678 A/A genotype was significantly associated with a higher proportion of MHC-I (p = 0.042) and with a lower proportion of MHC-IIx (p = 0.033), and the NRF1 rs6949152 AA genotype was significantly associated with a higher proportion of MHC-I (p = 0.008) and with a lower proportion of MHC IIx (p = 0.035). In women, the genotype scores of the modes presenting the most significant results for PPARGC1A rs8192678 G/A (Gly482Ser) and NRF1 rs6949152 A/G polymorphisms were significantly associated with MHC-I (p = 0.0007) and MHC IIx (p = 0.0016). That is, women with combined PPARGC1A A/A and NRF1 A/A genotypes presented the highest proportion of MHC-I and the lowest proportion of MHC-IIx, in contrast to women with combined PPARGC1A GG+GA and NRF1 AG+GG genotypes, who presented the lowest proportion of MHC-I and the highest proportion of MHC-IIx. Our results suggest possible associations between these polymorphisms (both individually and in combination) and the inter-individual variability observed in muscle fiber composition in women, but not in men. ; JSPS KAKENHI (16KK0188 to N.F) ; MEXT-Supported Program for the Strategic Research Foundation at Private Universities (to Juntendo University and Fukuoka University) ; 4.096 JCR (2020) Q2, ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2073-4425 |
| العلاقة: | Yvert, T., Miyamoto-Mikami, E., Tobina, T., Shiose, K., Kakigi, R., Tsuzuki, T., Takaragawa, M., Ichinoseki-Sekine, N., Pérez Ruiz, M., Kobayashi, H., Tanaka, H., Naito, H., & Fuku, N. (2020). PPARGC1A rs8192678 and NRF1 rs6949152 Polymorphisms Are Associated with Muscle Fiber Composition in Women. Genes, 11(9), 1012. https://doi.org/10.3390/genes11091012Test; http://hdl.handle.net/11268/9264Test |
| DOI: | 10.3390/genes11091012 |
| الإتاحة: | https://doi.org/10.3390/genes11091012Test http://hdl.handle.net/11268/9264Test |
| حقوق: | Attribution-NonCommercial-NoDerivatives 4.0 Internacional ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; openAccess |
| رقم الانضمام: | edsbas.589A61BA |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20734425 |
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| DOI: | 10.3390/genes11091012 |