دورية أكاديمية
Genes Interacting with Occupational Exposures to Low Molecular Weight Agents and Irritants on Adult-Onset Asthma in Three European Studies
| العنوان: | Genes Interacting with Occupational Exposures to Low Molecular Weight Agents and Irritants on Adult-Onset Asthma in Three European Studies |
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| المؤلفون: | Rava, Marta, Ahmed, Ismail, Kogevinas, Manolis, Le Moual, Nicole, Bouzigon, Emmanuelle, Curjuric, Ivan, Dizier, Marie-Hélène, Dumas, Orianne, Gonzalez, Juan R, Imboden, Medea, Mehta, Amar J, Tubert-Bitter, Pascale, Zock, Jan-Paul, Jarvis, Deborah, Probst-Hensch, Nicole M, Demenais, Florence, Nadif, Rachel |
| المساهمون: | French National Agency of Research (Francia), Unión Europea. Comisión Europea, Wellcome Trust |
| بيانات النشر: | National Institute of Environmental Health Sciences (NIEHS) |
| سنة النشر: | 2017 |
| المجموعة: | REPISALUD (REPositorio Institucional en SALUD del Instituto de Salud Carlos III - ISCIII) |
| مصطلحات موضوعية: | Adult, Asthma, Europe, Female, Humans, Irritants, Male, Middle Aged, Molecular Weight, NF-kappa B, Occupational Diseases, Occupational Exposure, Particulate Matter, Polymorphism, Single Nucleotide |
| الوصف: | BACKGROUND: The biological mechanisms by which cleaning products and disinfectants-an emerging risk factor-affect respiratory health remain incompletely evaluated. Studying genes by environment interactions (G × E) may help identify new genes related to adult-onset asthma. OBJECTIVES: We identified interactions between genetic polymorphisms of a large set of genes involved in the response to oxidative stress and occupational exposures to low molecular weight (LMW) agents or irritants on adult-onset asthma. METHODS: Our data came from three large European cohorts: Epidemiological Family-based Study of the Genetics and Environment of Asthma (EGEA), Swiss Cohort Study on Air Pollution and Lung and Heart Disease in Adults (SAPALDIA), and European Community Respiratory Health Survey in Adults (ECRHS). A candidate pathway-based strategy identified 163 genes involved in the response to oxidative stress and potentially related to exposures to LMW agents/irritants. Occupational exposures were evaluated using an asthma job-exposure matrix and job-specific questionnaires for cleaners and healthcare workers. Logistic regression models were used to detect G × E interactions, adjusted for age, sex, and population ancestry, in 2,599 adults (mean age, 47 years; 60% women, 36% exposed, 18% asthmatics). p-Values were corrected for multiple comparisons. RESULTS: Ever exposure to LMW agents/irritants was associated with current adult-onset asthma [OR = 1.28 (95% CI: 1.04, 1.58)]. Eight single nucleotide polymorphism (SNP) by exposure interactions at five loci were found at p < 0.005: PLA2G4A (rs932476, chromosome 1), near PLA2R1 (rs2667026, chromosome 2), near RELA (rs931127, rs7949980, chromosome 11), PRKD1 (rs1958980, rs11847351, rs1958987, chromosome 14), and PRKCA (rs6504453, chromosome 17). Results were consistent across the three studies and after accounting for smoking. CONCLUSIONS: Using a pathway-based selection process, we identified novel genes potentially involved in adult asthma by interaction with occupational ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0091-6765 1552-9924 |
| العلاقة: | Publisher's version; https://doi.org/10.1289/EHP376Test.; Environ Health Perspect. 2017;125(2):207-214.; http://hdl.handle.net/20.500.12105/7439Test; Environmental health perspectives |
| DOI: | 10.1289/EHP376 |
| الإتاحة: | https://doi.org/20.500.12105/7439Test https://doi.org/10.1289/EHP376Test https://hdl.handle.net/20.500.12105/7439Test |
| حقوق: | http://creativecommons.org/licenses/by/4.0Test/ ; Atribución 4.0 Internacional ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.586196B6 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00916765 15529924 |
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| DOI: | 10.1289/EHP376 |