دورية أكاديمية
Prognostic Role of Late Gadolinium Enhancement in Patients With Hypertrophic Cardiomyopathy and Low-to-Intermediate Sudden Cardiac Death Risk Score
| العنوان: | Prognostic Role of Late Gadolinium Enhancement in Patients With Hypertrophic Cardiomyopathy and Low-to-Intermediate Sudden Cardiac Death Risk Score |
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| المؤلفون: | Todiere, Giancarlo, Nugara, Cinzia, Gentile, Giovanni, Negri, Francesco, Bianco, Francesco, Falletta, Calogero, Novo, Giuseppina, Di Bella, Gianluca, De Caterina, Raffaele, Zachara, Elisabetta, Re, Federica, Clemenza, Francesco, Sinagra, Gianfranco, Emdin, Michele, Aquaro, Giovanni Donato |
| المساهمون: | Todiere, Giancarlo, Nugara, Cinzia, Gentile, Giovanni, Negri, Francesco, Bianco, Francesco, Falletta, Calogero, Novo, Giuseppina, Di Bella, Gianluca, De Caterina, Raffaele, Zachara, Elisabetta, Re, Federica, Clemenza, Francesco, Sinagra, Gianfranco, Emdin, Michele, Aquaro, Giovanni Donato |
| سنة النشر: | 2019 |
| المجموعة: | ARPI - Archivio della Ricerca dell'Università di Pisa |
| مصطلحات موضوعية: | Cardiomyopathy, Hypertrophic, Contrast Media, Death, Sudden, Cardiac, Female, Follow-Up Studie, Gadolinium, Heart Ventricle, Human, Incidence, Italy, Magnetic Resonance Imaging, Cine, Male, Middle Aged, Myocardium, Prognosi, ROC Curve, Retrospective Studie, Risk Assessment, Risk Factor, Survival Rate, Ventricular Function, Left |
| الوصف: | Sudden cardiac death (SCD) is the most life-threating complication of hypertrophic cardiomyopathy. Guidelines of the European Society of Cardiology (ESC) suggest the implantation of an implantable cardioverter defibrillator in primary prevention according to a 5-year risk SCD score >= 6%. The aim of the study is to evaluate the prognostic role of late gadolinium enhancement (LGE) in patients with a 5-year risk SCD score <6%. In this multicenter study, we performed cardiac magnetic resonance in 354 consecutive hypertrophic cardiomy-opathy patients (257 males, range of age 54 +/- 17) with a risk SCD score <6% (302 with <4% and 52 with >= 4 and <6% risk). Hard cardiac events, including SCD, resuscitated cardiac arrest, appropriate implantable cardioverter defibrillator interventions, sustained ventricular tachycardia, occurred in 22 patients. LGE was detected in a high proportion (92%) of patients with hard cardiac events (p = 0.002). At receiver-operating characteristic curve analysis, LGE extent >= 10% was the best threshold to predict major arrhythmic events (area under the curve: 0.74). Kaplan-Meier curves showed that patients with LGE >= 10% had a worse prognosis than those with lower extent (p < 0.0001). LGE extent was the best independent predictor of hard cardiac events (hazard ratio 1.05; 95% confidence interval [CI] 1.03 to 107; p < 0.0001). The estimates 5-year risk of hard cardiac event was 2.5% (95% CI 0.8 to 4.2) in patients with LGE extent <10% and 23.4% (95% CI 10.2 to 36.5) for those with LGE extent >= 10%. In conclusion, this study demonstrates as the extent of LGE >= 10% is able to recognize additional patients at increased risk for malignant arrhythmic episodes in a population with low-to-intermediate ESC SCD risk score. (C) 2019 Elsevier Inc. All rights reserved. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/31447011; info:eu-repo/semantics/altIdentifier/wos/WOS:000491215600019; volume:124; issue:8; firstpage:1286; lastpage:1292; numberofpages:7; journal:THE AMERICAN JOURNAL OF CARDIOLOGY; https://hdl.handle.net/11568/1156225Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85070893303 |
| DOI: | 10.1016/j.amjcard.2019.07.023 |
| الإتاحة: | https://doi.org/10.1016/j.amjcard.2019.07.023Test https://hdl.handle.net/11568/1156225Test |
| رقم الانضمام: | edsbas.585977E2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.amjcard.2019.07.023 |
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