التفاصيل البيبلوغرافية
| العنوان: |
Linear interactions between intraocular, intracranial pressure, and retinal vascular pulse amplitude in the fourier domain |
| المؤلفون: |
Abdul-Rahman, Anmar, Morgan, William, Jo Khoo, Ying, Lind, Christopher, Kermode, Allan, Carroll, William, Yu, Dao-Yi |
| المساهمون: |
Harris, Alon |
| المصدر: |
PLOS ONE ; volume 17, issue 6, page e0270557 ; ISSN 1932-6203 |
| بيانات النشر: |
Public Library of Science (PLoS) |
| سنة النشر: |
2022 |
| المجموعة: |
PLOS Publications (via CrossRef) |
| الوصف: |
Purpose To compare the retinal vascular pulsatile characteristics in subjects with normal (ICP n ) and high (ICP h ) intracranial pressure and quantify the interactions between intraocular pressure, intracranial pressure, and retinal vascular pulse amplitude in the Fourier domain. Materials and methods Twenty-one subjects were examined using modified photoplethysmography with simultaneous ophthalmodynamometry. A harmonic regression model was fitted to each pixel in the time-series, and used to quantify the retinal vascular pulse wave parameters including the harmonic regression wave amplitude (HRW a ). The pulse wave attenuation was measured under different ranges of induced intraocular pressure (IOP i ), as a function of distance along the vessel (V Dist ). Intracranial pressure (ICP) was measured using lumbar puncture. A linear mixed-effects model was used to estimate the correlations between the Yeo-Johnson transformed harmonic regression wave amplitude (HRW a-YJt ) with the predictors (IOP i , V Dist and ICP). A comparison of the model coefficients was done by calculating the weighted Beta ( β x ) coefficients. Results The median HRW a in the ICP n group was higher in the retinal veins (4.563, interquartile range (IQR) = 3.656) compared to the retinal arteries (3.475, IQR = 2.458), p<0.0001. In contrast, the ICP h group demonstrated a reduction in the median venous HRW a (3.655, IQR = 3.223) and an elevation in the median arterial HRW a (3.616, IQR = 2.715), p<0.0001. Interactions of the pulsation amplitude with ICP showed a significant disordinal interaction and the loss of a main effect of the Fourier sine coefficient (b n1 ) in the ICP h group, suggesting that this coefficient reflects the retinal vascular response to ICP wave. The linear mixed-effects model (LME) showed the decay in the venous (HRW a-YJt ) was almost twice that in the retinal arteries (−0.067±0.002 compared to −0.028±0.0021 respectively, p<0.00001). The overall interaction models had a total explanatory power of (conditional R 2 ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1371/journal.pone.0270557 |
| الإتاحة: |
https://doi.org/10.1371/journal.pone.0270557Test |
| حقوق: |
http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.5828C932 |
| قاعدة البيانات: |
BASE |
