دورية أكاديمية
Chromatin remodelling by polyamines and polyamine analogues
| العنوان: | Chromatin remodelling by polyamines and polyamine analogues |
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| المؤلفون: | PASINI, ALICE, GIORDANO, EMANUELE DOMENICO, Caldarera CM |
| المساهمون: | Pasini A, Caldarera CM, GIORDANO E |
| سنة النشر: | 2014 |
| المجموعة: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| مصطلحات موضوعية: | polyamine, epigenetic, chromatin, histone acetyltransferase, histone deacetylase, histone demethylases |
| الوصف: | Natural polyamines are involved in many molecular processes, including maintenance of DNA structure and RNA processing and translation. Our aim here is to present an overview of the literature concerning the significance of polyamines in the modulation of chromatin arrangement and the transcriptional regulation of gene expression. The pleiotropic picture emerging from the published data highlights that these polycations take part in apparently diverging effects, possibly depending on the heterogeneous experimental settings described, and on a methodological approach aimed at the evaluation of the global levels of the histone chemical modifications. Since the relevant changes observed appear to be rather local and gene specific, investigating histone modifications at the level of specific gene promoters of interest is thus to be recommended for future studies. Furthermore, decoding the multiple regulatory mechanisms by which polyamines exert their influence on chromatin-modifier enzymes will reasonably require focus on selected individual polyamine regulated genes. The evaluation of the many known chromatin- remodeling enzymes for their individual susceptibility to polyamines or polyamine derivatives will also be helpful: determining how they discriminate between the different enzyme isoforms is expected to be a fruitful line of research for drug discovery, e.g., in cancer prevention and therapy. Indeed, polyamine derivatives acting as epigenetic modulators appear to be molecules with great potential as antitumor drugs. All these novel polyamine-based pharmacologically active molecules are thus promising tools, both as a stand-alone strategy and in combination with other anticancer compounds. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/23836422; info:eu-repo/semantics/altIdentifier/wos/WOS:000331958900012; volume:46; issue:3; firstpage:595; lastpage:603; numberofpages:9; journal:AMINO ACIDS; http://hdl.handle.net/11585/154340Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84896316506 |
| DOI: | 10.1007/s00726-013-1550-9 |
| الإتاحة: | https://doi.org/10.1007/s00726-013-1550-9Test http://hdl.handle.net/11585/154340Test |
| رقم الانضمام: | edsbas.57F31C73 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00726-013-1550-9 |
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