دورية أكاديمية
Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression
| العنوان: | Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression |
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| المؤلفون: | Bruin, Ruben G. de, Shiue, Lily, Prins, Jurrien, Boer, Hetty C. de, Singh, Anjana, Fagg, W. Samuel, Gils, Janine M. vans, Duijs, Jacques M. G. J., Katzman, Sol, Kraaijeveld, Adriaan O., Bohringer, Stefan, Leung, Wai Y., Kielbasa, Szymon M., Donahue, John P., Zande, Patrick H. J. van der, Sijbom, Rick, Alem, Carla M. A. van, Bot, Ilze, Kooten, Cees van, Jukema, J. Wouter, Van Esch, Hilde, Rabelink, Ton J., Kazan, Hilal, Biessen, Erik A. L., Ares, Manuel, Zonneveld, Anton Jan van, Veer, Eric P. van der |
| المساهمون: | 0000-0003-2461-4579 Kazan, Hilal, Kazan, Hilal, 107780 Kazan, Hilal, 35094213400 Kazan, Hilal |
| بيانات النشر: | Nature Communications |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Stimulating factor-receptor, Binding protein, Critical regulator, Dendritic cells, Mutant mice, Uyarıcı faktör reseptörü, Bağlayıcı protein, Hassas regülatör, Dentritik hücreler, Mutant fareler |
| الوصف: | A hallmark of inflammatory diseases is the excessive recruitment and influx of monocytes to sites of tissue damage and their ensuing differentiation into macrophages. Numerous stimuli are known to induce transcriptional changes associated with macrophage phenotype, but posttranscriptional control of human macrophage differentiation is less well understood. Here we show that expression levels of the RNA-binding protein Quaking (QKI) are low in monocytes and early human atherosclerotic lesions, but are abundant in macrophages of advanced plaques. Depletion of QKI protein impairs monocyte adhesion, migration, differentiation into macrophages and foam cell formation in vitro and in vivo. RNA-seq and microarray analysis of human monocyte and macrophage transcriptomes, including those of a unique QKI haploinsufficient patient, reveal striking changes in QKI-dependent messenger RNA levels and splicing of RNA transcripts. The biological importance of these transcripts and requirement for QKI during differentiation illustrates a central role for QKI in posttranscriptionally guiding macrophage identity and function. ; No sponsor |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| ردمك: | 978-0-00-373153-8 0-00-373153-7 |
| تدمد: | 2041-1723 |
| العلاقة: | International publication; Bruin, R., Shiue, L., Prins, J., Boer, H., Singh, A., Fagg, W. S., Gils, J. M., Duijs, J. M. G. J., Katzman, S., Kraaijeveld, A. O., Bohringer, S., Leung, W. Y., Kielbasa, S. M., Donahue, J. P., Zande, P. H. J., Sijbom, R., Alem, C. M. A., Bot, I., Kooten, C., Jukema, J. W., Van Esch, H., Rabelink, T. J., Kazan, H., Biessen, E. A. L., Ares, M., Zonneveld & A. J., Veer, E. P. (2016). Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression. Nature Communications, 1-20.; http://hdl.handle.net/20.500.12566/182Test; WOS:000373153700001; 2-s2.0-84962247756; 20 |
| DOI: | 10.1038/ncomms10846 |
| الإتاحة: | https://doi.org/20.500.12566/182Test https://doi.org/10.1038/ncomms10846Test https://hdl.handle.net/20.500.12566/182Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.57D8E26B |
| قاعدة البيانات: | BASE |
Full Text Finder | ردمك: | 9780003731538 0003731537 |
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| تدمد: | 20411723 |
| DOI: | 10.1038/ncomms10846 |