دورية أكاديمية
“To Anticipate”: Neoadjuvant Therapy in Melanoma with a Focus on Predictive Biomarkers
| العنوان: | “To Anticipate”: Neoadjuvant Therapy in Melanoma with a Focus on Predictive Biomarkers |
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| المؤلفون: | Garutti M., Buriolla S., Bertoli E., Vitale M. G., Rossi E., Schinzari G., Minisini A. M., Puglisi F. |
| المساهمون: | Garutti, M., Buriolla, S., Bertoli, E., Vitale, M. G., Rossi, E., Schinzari, G., Minisini, A. M., Puglisi, F. |
| سنة النشر: | 2020 |
| المجموعة: | Università degli Studi di Udine: CINECA IRIS |
| مصطلحات موضوعية: | Adjuvant, BRAF, Immunotherapy, MEK, Melanoma, Neoadjuvant |
| الوصف: | Despite surgical resection and adjuvant therapies, stage III melanomas still have a substantial risk of relapse. Neoadjuvant therapy is an emerging strategy that might offer superior efficacy compared to adjuvant therapy. Moreover, neoadjuvant therapy has some virtual advantages: it might allow for less demolitive surgery, permit the in vivo evaluation of drug efficacy, help tailor adjuvant treatments, and play a crucial role in innovative translational research. Herein, we review the available literature to explore the scientific background behind the neoadjuvant approach. We also discuss published clinical trials with a focus on predictive biomarkers and ongoing studies. Finally, we outline a possible framework for future neoadjuvant clinical trial development based on the International Neoadjuvant Melanoma Consortium guidelines. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000554179400001; volume:12; issue:7; firstpage:1; lastpage:19; numberofpages:19; journal:CANCERS; http://hdl.handle.net/11390/1188798Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85088412916 |
| DOI: | 10.3390/cancers12071941 |
| الإتاحة: | https://doi.org/10.3390/cancers12071941Test http://hdl.handle.net/11390/1188798Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.57B6445D |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cancers12071941 |
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