دورية أكاديمية
P3520Admission hyperglycemia is a predictor of mortality of acute heart failure: comparison between patients with and without diabetes mellitus
العنوان: | P3520Admission hyperglycemia is a predictor of mortality of acute heart failure: comparison between patients with and without diabetes mellitus |
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المؤلفون: | Cho, J Y, Kim, K H, Lee, S E, Lee, H Y, Choi, J O, Jeon, E S, Kim, M S, Kim, J J, Hwang, K K, Chae, S C, Kang, S M, Choi, D J, Yoo, B S, Cho, M C, Oh, B H |
المصدر: | European Heart Journal ; volume 40, issue Supplement_1 ; ISSN 0195-668X 1522-9645 |
بيانات النشر: | Oxford University Press (OUP) |
سنة النشر: | 2019 |
مصطلحات موضوعية: | Cardiology and Cardiovascular Medicine |
الوصف: | Background Regardless of diabetes mellitus (DM), admission hyperglycemia is not uncommon in patients with acute heart failure (AHF). Although DM is a well-known predictor of mortality in AHF, the impacts of admission hyperglycemia on clinical outcomes in non-DM patients with AHF have been poorly studied. The aim of this study, therefore, was to compare the impact of admission hyperglycemia on long-term clinical outcomes in AHF patients with or without DM. Methods Among 5,625 AHF patients enrolled in a nationwide registry, a total of 5,541 patients were enrolled and divided into 2 groups; DM group (n=2,125, 70.4±11.4 years) vs. non-DM group (n=3,416, 67.3±16.0 years). Each group were further divided into 2 groups according to the presence of admission hyperglycemia (admission serum glucose level >200mg/dl); admission hyperglycemia (n=248) and no hyperglycemia (n=3,168) in non-DM; admission hyperglycemia (n=799) and no hyperglycemia (n=1,326) in DM. All-cause death and hospitalization due to HF (HHF) during 1-year follow-up were compared. Results Death was developed in 1,220 patients (22.2%) including 269 inhospital deaths (4.9%) during 1-year of follow-up. Death rate were significantly higher in DM than in non-DM group (24.8% vs 20.5%, p<0.001), however there was no difference in inhospital death (5.1% vs 4.7%, p=0.534). Both inhospital death (7.6% vs. 4.2%, p<0.001) and 1-year death (26.2% vs. 21.3%, p=0.001) were more frequent in AHF patients with hyperglycemia. On Kaplan-Meier survival curve analysis, however, admission hyperglycemia was associated with significantly higher death (p<0.001 by log-rank test) and rehospitalization (p=0.006 by log-rank test) in non-DM group, but not in DM group. In non-DM group, admission hyperglycemia was an independent predictor of 1-year mortality (HR 1.46, 95% CI 1.10–1.93, p=0.009). Conclusion DM was a significant predictor of long-term mortality in patients with AHF. Admission hyperglycemia was associated with both higher inhospital and 1-year mortality. ... |
نوع الوثيقة: | article in journal/newspaper |
اللغة: | English |
DOI: | 10.1093/eurheartj/ehz745.0384 |
الإتاحة: | https://doi.org/10.1093/eurheartj/ehz745.0384Test http://academic.oup.com/eurheartj/article-pdf/40/Supplement_1/ehz745.0384/30198572/ehz745.0384.pdfTest |
حقوق: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelTest |
رقم الانضمام: | edsbas.57905D3C |
قاعدة البيانات: | BASE |
DOI: | 10.1093/eurheartj/ehz745.0384 |
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