التفاصيل البيبلوغرافية
| العنوان: |
Target and Semitarget Analysis of Advanced Glycation End Products Using a New Pair of Permanently Positively Charged Stable Isotope Labeling Agents |
| المؤلفون: |
Shijuan Zhang, Xueting Wang, Kaiyue Zhang, Keyu Lin, Wenjie Lu, Keke Lu, Yanxin Li |
| سنة النشر: |
2024 |
| المجموعة: |
Smithsonian Institution: Figshare |
| مصطلحات موضوعية: |
Biochemistry, Genetics, Biotechnology, Sociology, Chemical Sciences not elsewhere classified, matrix effect ranged, mass spectrometry response, approximately 2 orders, 0 – 23, within 5 min, 1 – 94, 13 ages identified, 1 – 7, common mrm parameters, 7 ng, 5 %, semitarget analysis, quantitation limits, precolumn labeling, mild conditions, age candidates, >< sub, 41 types |
| الوصف: |
A pair of positively charged stable isotope labeling (SIL) agents, (4-carbonochloridoylphenyl)-trimethylazanium iodide ( d 0 -CCPTA) and d 6 -CCPTA, were designed and synthesized. These agents were employed in the precolumn labeling of advanced glycation end products (AGEs) within 5 min under mild conditions. Through derivatization, the mass spectrometry response of the AGEs was enhanced by approximately 2 orders of magnitude. The detection and quantitation limits were in the ranges of 3.1–7.1 and 10.0–23.7 ng/kg, respectively. The recoveries were in the range of 90.1–94.3%, and the matrix effect ranged from −6.6 to −3.5%. CCPTA produced “CCPTA-specific production ions”, and all analytes were analyzed by common multiple reaction monitoring (MRM) parameters. The common MRM parameters were applied to the semitarget analysis of 41 types of AGE candidates in the absence of standards, with 13 AGEs identified. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Target_and_Semitarget_Analysis_of_Advanced_Glycation_End_Products_Using_a_New_Pair_of_Permanently_Positively_Charged_Stable_Isotope_Labeling_Agents/25219404Test |
| DOI: |
10.1021/acs.jafc.3c09043.s001 |
| الإتاحة: |
https://doi.org/10.1021/acs.jafc.3c09043.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.5789158B |
| قاعدة البيانات: |
BASE |
