مؤتمر
Magnetic resonance imaging of migrating neuronal precursors in normal and hypoxic-ischemic neonatal rat brains by intraventricular MPIO labeling
| العنوان: | Magnetic resonance imaging of migrating neuronal precursors in normal and hypoxic-ischemic neonatal rat brains by intraventricular MPIO labeling |
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| المؤلفون: | Niu, G, Yang, J, Liu, J, Liu, Y, Wu, EX |
| بيانات النشر: | //www.ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269 United States |
| سنة النشر: | 2008 |
| المجموعة: | University of Hong Kong: HKU Scholars Hub |
| مصطلحات موضوعية: | Brain - pathology, Cerebral Ventricles - pathology, Ferric Compounds - diagnostic use, Hypoxia-Ischemia, Image Enhancement - methods |
| الوصف: | Proceedings of the IEEE Engineering in Medicine and Biology Society Conference, 2008, p. 363-366 ; In this study, 10-day-old normal rats (n=6) and hypoxic-ischemic (H-I) neonatal rats (n=6) were injected with the micronsized iron oxide particles (MPIOs) into the anterior lateral ventricle. 2D and 3D high-spatial resolution MRI were performed with a 7T animal scanner 1 day before the MPIOs injection and hour 3, day 3, day 7 and day 14 after the MPIOs injection. Intraperitoneal injections of 5-bromo-2'-deoxyuridine (BrdU) were used to label newly produced cells, and were given thrice daily for 2 days before sacrifice. Immunohistochemistry and Prussian blue staining indicated that iron particles were inside the nestin+ and BrdU+ neural progenitor cells (NPCs), glial-fibrillary-acidic-protein-positive (GFAP+) astrocytes-like progenitor cells, and neuronal-nuclei-positive (NeuN+) mature neurons. Here we demonstrate that, in normal neonatal rat brain, the migrating pathway of the endogenous NPCs with MPIO is mainly along the rostral migratory stream to the olfactory bulb. In H-I neonatal rat brain, the migration of endogenous NPCs with MPIO is mainly towards the ischemic regions. Therefore, in vivo magnetic cell labeling of endogenous NPCs with MPIO and subsequently non-invasive, serial MRI monitoring should open up a new approach to probe into the mechanism of cell migration in the developmental brain under physiological and pathologic conditions. © 2008 IEEE. ; published_or_final_version |
| نوع الوثيقة: | conference object |
| اللغة: | English |
| تدمد: | 1557-170X |
| العلاقة: | Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"; http://www.scopus.com/mlt/select.url?eid=2-s2.0-61849126270&selection=ref&src=s&origin=recordpageTest; Proceedings Of The 30Th Annual International Conference Of The Ieee Engineering In Medicine And Biology Society, Embs'08 - Personalized Healthcare Through Technology, 2008, p. 363-366; 366; 161995; http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1557-170X&volume=&spage=363&epage=366&date=2008&atitle=Magnetic+resonance+imaging+of+migrating+neuronal+precursors+in+normal+and+hypoxic-ischemic+neonatal+rat+brains+by+intraventricular+MPIO+labelingTest; eid_2-s2.0-61849126270; 363; http://hdl.handle.net/10722/62061Test |
| DOI: | 10.1109/IEMBS.2008.4649165 |
| الإتاحة: | https://doi.org/10.1109/IEMBS.2008.4649165Test http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1557-170X&volume=&spage=363&epage=366&date=2008&atitle=Magnetic+resonance+imaging+of+migrating+neuronal+precursors+in+normal+and+hypoxic-ischemic+neonatal+rat+brains+by+intraventricular+MPIO+labelingTest http://hdl.handle.net/10722/62061Test |
| حقوق: | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. ; ©2008 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE. ; IEEE Engineering in Medicine and Biology Society. Conference Proceedings. Copyright © IEEE. |
| رقم الانضمام: | edsbas.575C48B0 |
| قاعدة البيانات: | BASE |
| تدمد: | 1557170X |
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| DOI: | 10.1109/IEMBS.2008.4649165 |