دورية أكاديمية
Effect of High-Definition Transcranial Direct Current Stimulation on Headache Severity and Central μ-Opioid Receptor Availability in Episodic Migraine
| العنوان: | Effect of High-Definition Transcranial Direct Current Stimulation on Headache Severity and Central μ-Opioid Receptor Availability in Episodic Migraine |
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| المؤلفون: | DaSilva,Alexandre F, Kim,Dajung J, Lim,Manyoel, Nascimento,Thiago D, Scott,Peter JH, Smith,Yolanda R, Koeppe,Robert A, Zubieta,Jon-Kar, Kaciroti,Niko |
| بيانات النشر: | Dove Press |
| سنة النشر: | 2023 |
| المجموعة: | Dove Medical Press |
| مصطلحات موضوعية: | Journal of Pain Research |
| الوصف: | Alexandre F DaSilva,1,2,* Dajung J Kim,1,2,* Manyoel Lim,1,2 Thiago D Nascimento,1,2 Peter JH Scott,3 Yolanda R Smith,4 Robert A Koeppe,3 Jon-Kar Zubieta,5 Niko Kaciroti6 1Headache and Orofacial Pain Effort (H.O.P.E.) Laboratory, Department of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, MI, USA; 2Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA; 3Department of Radiology, University of Michigan, Ann Arbor, MI, USA; 4Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA; 5Department of Psychiatry, Mass General Brigham, Newton-Wellesley Hospital, Newton, MA, USA; 6Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA*These authors contributed equally to this workCorrespondence: Alexandre F DaSilva, Headache and Orofacial Pain Effort (H.O.P.E.) Laboratory, Michigan Neuroscience Institute, 205 Zina Pitcher PI, Room 1021, Ann Arbor, MI, 48109-5720, USA, Email adasilva@umich.eduObjective: The current understanding of utilizing HD-tDCS as a targeted approach to improve headache attacks and modulate endogenous opioid systems in episodic migraine is relatively limited. This study aimed to determine whether high-definition transcranial direct current stimulation (HD-tDCS) over the primary motor cortex (M1) can improve clinical outcomes and endogenous μ-opioid receptor (μOR) availability for episodic migraineurs.Methods: In a randomized, double-blind, and sham-controlled trial, 25 patients completed 10-daily 20-min M1 HD-tDCS, repeated Positron Emission Tomography (PET) scans with a selective agonist for μOR. Twelve age- and sex-matched healthy controls participated in the baseline PET/MRI scan without neuromodulation. The primary endpoints were moderate-to-severe (M/S) headache days and responder rate (≥ 50% reduction on M/S headache days from baseline), and secondary endpoints included the presence of M/S headache intensity and the use of rescue medication over 1-month after ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | https://www.dovepress.com/effect-of-high-definition-transcranial-direct-current-stimulation-on-h-peer-reviewed-fulltext-article-JPRTest |
| الإتاحة: | https://doi.org/10.2147/JPR.S407738Test https://www.dovepress.com/effect-of-high-definition-transcranial-direct-current-stimulation-on-h-peer-reviewed-fulltext-article-JPRTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.575C308F |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |