دورية أكاديمية
Surface area in the insula was associated with 28-month functional outcome in first-episode psychosis
| العنوان: | Surface area in the insula was associated with 28-month functional outcome in first-episode psychosis |
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| المؤلفون: | Shinsuke Koike, Mao Fujioka, Yoshihiro Satomura, Daisuke Koshiyama, Mariko Tada, Eisuke Sakakibara, Naohiro Okada, Yosuke Takano, Norichika Iwashiro, Tatsunobu Natsubori, Yinghan Zhu, Osamu Abe, Kenji Kirihara, Hidenori Yamasue, Kiyoto Kasai |
| المصدر: | npj Schizophrenia, Vol 7, Iss 1, Pp 1-7 (2021) |
| بيانات النشر: | Nature Portfolio Nature Publishing Group UK |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Psychiatry, RC435-571, psy, stat |
| الوصف: | Many studies have tested the relationship between demographic, clinical, and psychobiological measurements and clinical outcomes in ultra-high risk for psychosis (UHR) and first-episode psychosis (FEP). However, no study has investigated the relationship between multi-modal measurements and long-term outcomes for >2 years. Thirty-eight individuals with UHR and 29 patients with FEP were measured using one or more modalities (cognitive battery, electrophysiological response, structural magnetic resonance imaging, and functional near-infrared spectroscopy). We explored the characteristics associated with 13- and 28-month clinical outcomes. In UHR, the cortical surface area in the left orbital part of the inferior frontal gyrus was negatively associated with 13-month disorganized symptoms. In FEP, the cortical surface area in the left insula was positively associated with 28-month global social function. The left inferior frontal gyrus and insula are well-known structural brain characteristics in schizophrenia, and future studies on the pathological mechanism of structural alteration would provide a clearer understanding of the disease. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1038/s41537-021-00186-9Test |
| DOI: | 10.1038/s41537-021-00186-9 |
| الإتاحة: | https://doi.org/10.1038/s41537-021-00186-9Test |
| حقوق: | undefined |
| رقم الانضمام: | edsbas.5756D5D8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41537-021-00186-9 |
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