دورية أكاديمية
InactivationofSirtuin2protectsmicefromacetaminophen-inducedliverinjury:possibleinvolvementofERstressandS6K2activation
| العنوان: | InactivationofSirtuin2protectsmicefromacetaminophen-inducedliverinjury:possibleinvolvementofERstressandS6K2activation |
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| المساهمون: | Da Hyun Lee, Buhyun Lee, Jeong Su Park, Yu Seol Lee, Jin Hee Kim, Yejin Cho, Yoonjung Jo, Hyun-Seok Kim, Yong-ho Lee, Ki Taek Nam, Soo Han Bae, Nam, Ki Taek |
| بيانات النشر: | Korean Society for Biochemistry and Molecular Biology |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Acetaminophen/adverse effects, Acetaminophen/pharmacology, Acetaminophen/toxicity, Animals, Chemical and Drug InducedLiverInjury/genetics, Chemical and Drug InducedLiverInjury/prevention & control, Endoplasmic ReticulumStress/physiology, Hepatocytes/metabolism, Liver/metabolism, Male, Mice, Inbred C57BL, Mitochondria,Liver/metabolism, Necrosis, OxidativeStress, Protective Agents, Ribosomal Protein S6 Kinases, 90-kDa/metabolism, 90-kDa/physiology, Sirtuin 2/genetics, Sirtuin 2/metabolism, Sirtuin 2/physiology, Acetaminophen, ER stress, Hepatotoxicity, S6K1, Sirtuin3 |
| الوصف: | Acetaminophen (APAP) overdose can cause hepatotoxicity by inducing mitochondrial damage and subsequent necrosis in hepatocytes. Sirtuin2 (Sirt3) is an NAD+-dependent deacetylase that regulates several biological processes, including hepatic gluconeogenesias well as inflammatory pathways. We show that APAP decreases the expression of Sirt2. Moreover, the ablation of Sirt2 attenuates APAP-induced liver injuries, such as oxidative stress and mitochondrial damage in hepatocytes. We found that Sirt2 deficiency alleviates the APAP-mediated endoplasmic reticulum (ER) stress and phosphorylation of the p70 ribosomal S6 kinase 1 (S6K1). Moreover, Sirt2 interacts with and deacetylates S6K1, followed by S6K1 phosphorylation induction. This study elucidates the molecular mechanisms underlying the protective role of Sirt2 inactivation in APAP-induced liver injuries. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1976-6696 1976-670X |
| العلاقة: | BMB REPORTS; J00348; OAK-2019-01953; https://ir.ymlib.yonsei.ac.kr/handle/22282913/170214Test; T201901878; BMB REPORTS, Vol.52(3) : 190-195, 2019; 64728 |
| DOI: | 10.5483/BMBRep.2019.52.3.083 |
| الإتاحة: | https://doi.org/10.5483/BMBRep.2019.52.3.083Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/170214Test |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ |
| رقم الانضمام: | edsbas.5747D00E |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19766696 1976670X |
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| DOI: | 10.5483/BMBRep.2019.52.3.083 |