دورية أكاديمية
Functional and morphological cardiovascular alterations associated with neurofibromatosis 1
| العنوان: | Functional and morphological cardiovascular alterations associated with neurofibromatosis 1 |
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| المؤلفون: | Cutruzzola A., Irace C., Frazzetto M., Sabatino J., Gullace R., De Rosa S., Spaccarotella C., Concolino D., Indolfi C., Gnasso A. |
| المساهمون: | Cutruzzola, A., Irace, C., Frazzetto, M., Sabatino, J., Gullace, R., De Rosa, S., Spaccarotella, C., Concolino, D., Indolfi, C., Gnasso, A. |
| بيانات النشر: | Nature Research |
| سنة النشر: | 2020 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: | Adolescent, Adult, Biomarker, Blood Viscosity, Cardiovascular Disease, Carotid Arterie, Female, Heart Function Test, Hemodynamic, Human, Male, Middle Aged, Neurofibromatosis 1, Young Adult, Disease Susceptibility |
| الوصف: | Subjects with Neurofibromatosis 1 (NF1) develop vascular complications. The protein product of the gene affected in NF1, neurofibromin, physiologically modulates endothelial function and preserves vascular and myocardial structure. Our study aimed to verify whether subjects with NF1 have early, preclinical abnormalities of carotid artery structure, brachial artery function, and cardiac function. We recruited 22 NF1 subjects without previous cardiovascular events and 22 healthy control subjects. All subjects underwent measurement of carotid artery intima-media thickness (IMT), evaluation of brachial artery endothelial function after ischemia and exercise, and cardiac function. Mean IMT was 543 ± 115 μ in NF1 subjects and 487 ± 70 μ in Controls (p < 0.01). Endothelial function was significantly dumped in NF1 subjects. The dilation after ischemia and exercise was respectively 7.5(± 4.8)% and 6.7(± 3.0)% in NF1 versus 10.5(± 1.2)% and 10.5(± 2.1)% in control subjects (p < 0.02; p < 0.002). Left ventricular systolic function assessed by Global Longitudinal Strain was significantly different between NF1 subjects and Controls: − 19.3(± 1.7)% versus − 21.5(± 2.7)% (p < 0.008). These findings demonstrate that NF1 patients have early morphological and functional abnormalities of peripheral arteries and systolic cardiac impairment and suggest the need for a tight cardiovascular risk evaluation and primary prevention in subjects with NF1. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/32694667; info:eu-repo/semantics/altIdentifier/wos/WOS:000555518700041; volume:10; issue:1; firstpage:12070; journal:SCIENTIFIC REPORTS; http://hdl.handle.net/11577/3402719Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85088302459 |
| DOI: | 10.1038/s41598-020-68908-0 |
| الإتاحة: | https://doi.org/10.1038/s41598-020-68908-0Test http://hdl.handle.net/11577/3402719Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5703AC42 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-020-68908-0 |
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