دورية أكاديمية
Composite Nanogels Based on Zeolite-Poly(ethylene glycol) Diacrylate for Controlled Drug Delivery
| العنوان: | Composite Nanogels Based on Zeolite-Poly(ethylene glycol) Diacrylate for Controlled Drug Delivery |
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| المؤلفون: | Spatarelu, Catalina Paula, (radu) Chiriac, Anita-Laura, Cursaru, Bogdan, Iordache, Tanta-Verona, Gavrila, Ana-Mihaela, Cojocaru, Crina-Thea, Botez, Razvan-Edward, Trica, Bogdan, Sarbu, Andrei, Teodorescu, Mircea, Tofan, Vlad, Perrin, Francois-Xavier, Zaharia, Anamaria |
| المساهمون: | The National Institute for Research & Development in Chemistry and Petrochemistry (ICECHIM), Laboratoire Matériaux Polymères Interfaces Environnement Marin - EA 4323 (MAPIEM), Université de Toulon (UTLN) |
| المصدر: | ISSN: 2079-4991. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2020 |
| المجموعة: | Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
| مصطلحات موضوعية: | composite nanogels, zeolite, poly(ethylene glycol) diacrylate, mini-emulsion polymerization, 5-FU, controlled release, [CHIM.MATE]Chemical Sciences/Material chemistry |
| الوصف: | International audience ; This study presents the design of novel composites nanogels, based on poly(ethylene glycol) diacrylate and natural zeolite particles, that are able to act as materials with controlled drug delivery properties. Natural zeolite–nanogels composite, with varying zeolite contents, were obtained by an inverse mini-emulsion technique and loaded with 5-fluorouracil, a widely used chemotherapeutic drug. Herein, the possibility of adjusting final properties by means of modifying the preparation conditions was investigated. The prepared composite nanogels are characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). In light of this tunable drug-loading capability, swelling behaviour, and cytotoxicity, these composite nanogels could be highly attractive as drug reservoirs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-03603297; https://hal.science/hal-03603297Test; PUBMEDCENTRAL: PMC7075022 |
| DOI: | 10.3390/nano10020195 |
| الإتاحة: | https://doi.org/10.3390/nano10020195Test https://hal.science/hal-03603297Test |
| رقم الانضمام: | edsbas.56DD4E52 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/nano10020195 |
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