دورية أكاديمية
Scaffold proteins in mammalian MAP kinase cascades
| العنوان: | Scaffold proteins in mammalian MAP kinase cascades |
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| المؤلفون: | Yoshioka Katsuji, 善岡 克次 |
| بيانات النشر: | 日本生化学会 = Japanese Biochemical Society |
| سنة النشر: | 2004 |
| المجموعة: | Kanazawa University Repository for Academic Resources (KURA) / 金沢大学学術情報リポジトリ |
| مصطلحات موضوعية: | ERK, JNK, Kinesin, p38, Signal transduction |
| الوصف: | 金沢大学がん研究所がん分子細胞制御 ; The mitogen-activated protein kinase (MAPK) signaling pathway, which is conserved from yeast to humans, is activated in response to a variety of extra- and intracellular stimuli, and plays key roles in multiple cellular processes, including proliferation, differentiation, and apoptosis. The MAPK pathway transmits its signal through the sequential phosphorylation of MAPK kinase kinase to MAPK kinase to MAPK. Specific and efficient activation of the MAPK cascades is crucial for proper cellular responses to stimuli. As shown in yeast, the mammalian MAPK signaling system may also employ scaffold proteins, in part, to organize the MAPK signaling components into functional MAPK modules, thereby enabling the efficient activation of specific MAPK pathways. This review article describes recent advances in the study of potential mammalian scaffold proteins that may help us understand the complex regulation, including the spatial and temporal control, of the mammalian MAPK signaling pathways. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0021-924X |
| العلاقة: | http://dx.doi.org/10.1093/jb/mvh079Test; http://jb.oxfordjournals.org/cgi/content/abstract/135/6/657Test; https://kanazawa-u.repo.nii.ac.jp/?action=repository_uri&item_id=27543Test; http://hdl.handle.net/2297/14547Test; Journal of Biochemistry, 135(6), 657-661(2004-06-01); AA00694073; https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27543&item_no=1&attribute_id=26&file_no=1Test |
| الإتاحة: | https://doi.org/10.1093/jb/mvh079Test http://hdl.handle.net/2297/14547Test https://kanazawa-u.repo.nii.ac.jp/?action=repository_uri&item_id=27543Test https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27543&item_no=1&attribute_id=26&file_no=1Test |
| حقوق: | © 2004 The Japanese Biochemical Society |
| رقم الانضمام: | edsbas.56B2F0B5 |
| قاعدة البيانات: | BASE |
| تدمد: | 0021924X |
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