دورية أكاديمية
Antibiotic-exposed patients with non-small-cell lung cancer preserve efficacy outcomes following first-line chemo-immunotherapy.
| العنوان: | Antibiotic-exposed patients with non-small-cell lung cancer preserve efficacy outcomes following first-line chemo-immunotherapy. |
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| المؤلفون: | Cortellini, Alessio, Ricciuti, Biagio, Facchinetti, Francesco, Alessi, João Victor Machado, Venkatraman, Deepti, Dall'Olio, Filippo G, Cravero, Paola, Vaz, Victor R, Ottaviani, Diego, Majem, Margarita, Piedra, Aida, Sullivan, Ivana, Lee, Karla A, Lamberti, Giuseppe, Hussain, Nadiya, Clark, Jeffrey, Bolina, Anita, Barba, Andrés, Benitez, José Carlos, GorrÃa, Teresa, Mezquita, Laura, Hoton, Delphine, Aboubakar Nana, Frank, Besse, Benjamin, Awad, Marc M, Pinato, David J |
| المساهمون: | UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de pneumologie, UCL - (SLuc) Service d'anatomie pathologique |
| المصدر: | Annals of oncology, Vol. 32, no.11, p. 1391-1399 (2021) |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2021 |
| المجموعة: | DIAL@UCL (Université catholique de Louvain) |
| مصطلحات موضوعية: | Anti-Bacterial Agents, Carcinoma, Non-Small-Cell Lung, Humans, Immunotherapy, Lung Neoplasms, Treatment Outcome, antibiotics, chemotherapy, immune checkpoint inhibitors, non-small-cell lung cancer, pembrolizumab, predictive factors |
| الوصف: | BACKGROUND: Prior antibiotic therapy (pATB) is known to impair efficacy of single-agent immune checkpoint inhibitors (ICIs), potentially through the induction of gut dysbiosis. Whether ATB also affects outcomes to chemo-immunotherapy combinations is still unknown. PATIENTS AND METHODS: In this international multicentre study, we evaluated the association between pATB, concurrent ATB (cATB) and overall survival (OS), progression-free survival (PFS) and objective response rate (ORR) in patients with non-small-cell lung cancer (NSCLC) treated with first-line chemo-immunotherapy at eight referral institutions. RESULTS: Among 302 patients with stage IV NSCLC, 216 (71.5%) and 61 (20.2%) patients were former and current smokers, respectively. Programmed death-ligand 1 tumour expression in assessable patients (274, 90.7%) was ≥50% in 76 (25.2%), 1%-49% in 84 (27.9%) and <1% in 113 (37.5%). Multivariable analysis showed pATB-exposed patients to have similar OS {hazard ratio (HR) = 1.42 [95% confidence interval (CI): 0.91-2.22]; P = 0.1207} and PFS [HR = 1.12 (95% CI: 0.76-1.63); P = 0.5552], compared to unexposed patients, regardless of performance status. Similarly, no difference with respect to ORR was found across pATB exposure groups (42.6% versus 57.4%, P = 0.1794). No differential effect was found depending on pATB exposure duration (≥7 versus <7 days) and route of administration (intravenous versus oral). Similarly, cATB was not associated with OS [HR = 1.29 (95% CI: 0.91-1.84); P = 0.149] and PFS [HR = 1.20 (95% CI: 0.89-1.63); P = 0.222] when evaluated as time-varying covariate in multivariable analysis. CONCLUSIONS: In contrast to what has been reported in patients receiving single-agent ICIs, pATB does not impair clinical outcomes to first-line chemo-immunotherapy of patients with NSCLC. pATB status should integrate currently available clinico-pathologic factors for guiding first-line treatment decisions, whilst there should be no concern in offering cATB during chemo-immunotherapy when needed. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0923-7534 1569-8041 |
| العلاقة: | boreal:253218; http://hdl.handle.net/2078.1/253218Test; info:pmid/34400292; urn:ISSN:0923-7534; urn:EISSN:1569-8041 |
| DOI: | 10.1016/j.annonc.2021.08.1744 |
| الإتاحة: | https://doi.org/10.1016/j.annonc.2021.08.1744Test http://hdl.handle.net/2078.1/253218Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.561A980 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 09237534 15698041 |
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| DOI: | 10.1016/j.annonc.2021.08.1744 |