دورية أكاديمية
Caveolin-1 mediates the utilization of extracellular proteins for survival in refractory gastric cancer
| العنوان: | Caveolin-1 mediates the utilization of extracellular proteins for survival in refractory gastric cancer |
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| المؤلفون: | Hwang, Nahee, Yoon, Bo Kyung, Chun, Kyu-Hye, Kim, Hyeonhui, Lee, Yoseob, Kim, Jae-Won, Jeon, Hyeonuk, Kim, Tae-Hyun, Kim, Mi-Young, Fang, Sungsoon, Cheong, Jae-Ho, Kim, Jae-woo |
| المساهمون: | National Research Foundation of Korea, Korea Health Industry Development Institute |
| المصدر: | Experimental & Molecular Medicine ; volume 55, issue 11, page 2461-2472 ; ISSN 2092-6413 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Clinical Biochemistry, Molecular Biology, Molecular Medicine, Biochemistry |
| الوصف: | Despite advances in cancer therapy, the clinical outcome of patients with gastric cancer remains poor, largely due to tumor heterogeneity. Thus, finding a hidden vulnerability of clinically refractory subtypes of gastric cancer is crucial. Here, we report that chemoresistant gastric cancer cells rely heavily on endocytosis, facilitated by caveolin-1, for survival. caveolin-1 was highly upregulated in the most malignant stem-like/EMT/mesenchymal (SEM)-type gastric cancer cells, allowing caveolin-1-mediated endocytosis and utilization of extracellular proteins via lysosomal degradation. Downregulation of caveolin-1 alone was sufficient to induce cell death in SEM-type gastric cancer cells, emphasizing its importance as a survival mechanism. Consistently, chloroquine, a lysosomal inhibitor, successfully blocked caveolin-1-mediated endocytosis, leading to the marked suppression of tumor growth in chemorefractory gastric cancer cells in vitro, including patient-derived organoids, and in vivo. Together, our findings suggest that caveolin-1-mediated endocytosis is a key metabolic pathway for gastric cancer survival and a potential therapeutic target. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s12276-023-01109-7 |
| الإتاحة: | https://doi.org/10.1038/s12276-023-01109-7Test https://www.nature.com/articles/s12276-023-01109-7.pdfTest https://www.nature.com/articles/s12276-023-01109-7Test |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.56008297 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s12276-023-01109-7 |
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