دورية أكاديمية
Livedoid Vasculopathy: A French Observational Study Including Therapeutic Options
| العنوان: | Livedoid Vasculopathy: A French Observational Study Including Therapeutic Options |
|---|---|
| المؤلفون: | Gardette, Emma, Moguelet, Philippe, Bouaziz, Jean David, Lipsker, Dan, Dereure, Olivier, Le Pelletier, François, Lok, Catherine, Maisonobe, Thierry, Bessis, Didier, Conard, Jacqueline, Frances, Camille, Barete, Stéphane |
| المساهمون: | Service de dermatologie et allergologie CHU Tenon, CHU Tenon AP-HP, Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'Histologie - Embryologie - Cytogénétique biologie tumorale et génétique moléculaire CHU Tenon, Hôpital Saint-Louis, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), CHU Strasbourg, CHU Montpellier, Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier )-Université de Montpellier (UM), CHU Pitié-Salpêtrière AP-HP, Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Amiens-Picardie, Service de Neurophysiologie Clinique CHU Pitié-Salpêtrière, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière AP-HP, Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Cochin AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Departement Hospitalo- Universitaire - Inflammation, Immunopathologie, Biothérapie Paris (DHU - I2B), CHU Trousseau APHP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Saint-Antoine AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière AP-HP |
| المصدر: | ISSN: 0001-5555 ; Acta Dermato-Venereologica ; https://hal.sorbonne-universite.fr/hal-01901846Test ; Acta Dermato-Venereologica, Society for Publication of Acta Dermato-Venereologica, 2018, 98 (9), pp.842 - 847. ⟨10.2340/00015555-2965⟩. |
| بيانات النشر: | HAL CCSD Society for Publication of Acta Dermato-Venereologica |
| سنة النشر: | 2018 |
| المجموعة: | Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
| مصطلحات موضوعية: | peripheral neuropathy, intravenous immunoglobulins, thrombophilia, low molecular weight heparin, thrombosis of dermal vessels, livedoid vasculopathy, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology |
| الوصف: | International audience ; Livedoid vasculopathy is a chronic thrombotic disease of the skin microcirculation resulting in painful ulcers mainly affecting the lower legs. This study presents a French cohort of patients with livedoid vasculopathy. It describes clinical, histological characteristics and outcome of patients. It notably shows a frequent thrombophilia background. Nerve damage can be associated with cutaneous manifestations. These data also confirm that heparin or oral anticoagulants are able to achieve a complete response. Refractory cases can be treated with intravenous immunoglobulins. Livedoid vasculopathy is a rare thrombotic cutaneous disease. This observational study aimed to assess the clinical and biological features of livedoid vasculopa thy and the efficacy of treatments. Patients enrolled had typical livedoid vasculopathy both clinically and histologically. Investigation of thrombophilia was per formed. Electromyography was undertaken in the pre sence of symptoms suggesting peripheral neuro pathy. Eighteen women and 8 men were included, with a mean age of 35.5 years at onset. Twenty patients had at least one thrombophilia factor. Ten patients had a peripheral neuropathy with 2 of these patients demon strating a specific thrombo-occlusive vasculopathy on muscle biopsy. Anticoagulation with low molecular weight heparin was the most prescribed therapy and was associated with the best outcome (effective in 14 patients). Eight patients had severe disease refractory to anticoagulation and required intravenous immuno globulins, producing a good response in 6 patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-01901846; https://hal.sorbonne-universite.fr/hal-01901846Test; https://hal.sorbonne-universite.fr/hal-01901846/documentTest; https://hal.sorbonne-universite.fr/hal-01901846/file/5236.pdfTest |
| DOI: | 10.2340/00015555-2965 |
| الإتاحة: | https://doi.org/10.2340/00015555-2965Test https://hal.sorbonne-universite.fr/hal-01901846Test https://hal.sorbonne-universite.fr/hal-01901846/documentTest https://hal.sorbonne-universite.fr/hal-01901846/file/5236.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.55DB7F38 |
| قاعدة البيانات: | BASE |
| DOI: | 10.2340/00015555-2965 |
|---|