دورية أكاديمية
Additive Impact of Interleukin 6 and Neuron Specific Enolase for Prognosis in Patients With Out-of-Hospital Cardiac Arrest – Experience From the HAnnover COoling REgistry
| العنوان: | Additive Impact of Interleukin 6 and Neuron Specific Enolase for Prognosis in Patients With Out-of-Hospital Cardiac Arrest – Experience From the HAnnover COoling REgistry |
|---|---|
| المؤلفون: | Muharrem Akin, Jan-Thorben Sieweke, Vera Garcheva, Carolina Sanchez Martinez, John Adel, Pia Plank, Paris Zandian, Kurt-Wolfram Sühs, Johann Bauersachs, Andreas Schäfer |
| المصدر: | Frontiers in Cardiovascular Medicine, Vol 9 (2022) |
| بيانات النشر: | Frontiers Media S.A. |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | out-of-hospital cardiac arrest, interleukin 6, neuron-specific enolase, neurological outcome, prognosis, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | BackgroundPatients after out-of-hospital cardiac arrest (OHCA) are at increased risk for mortality and poor neurological outcome. We assessed the additive impact of interleukin 6 (IL-6) at admission to neuron-specific enolase (NSE) at day 3 for prognosis of 30-day mortality and long-term neurological outcome in OHCA patients.MethodsA total of 217 patients from the HAnnover COoling REgistry with return of spontaneous circulation (ROSC) after OHCA and IL-6 measurement immediately after admission during 2017–2020 were included to investigate the prognostic value and importance of IL-6 in addition to NSE obtained on day 3. Poor neurological outcome was defined by cerebral performance category (CPC) ≥ 3 after 6 months.ResultsPatients with poor outcome showed higher IL-6 values (30-day mortality: 2,224 ± 524 ng/l vs 186 ± 15 ng/l, p < 0.001; CPC ≥ 3 at 6 months: 1,440 ± 331 ng/l vs 180 ± 24 ng/l, p < 0.001). IL-6 was an independent predictor of mortality (HR = 1.013/ng/l; 95% CI 1.007–1.019; p < 0.001) and poor neurological outcome (HR = 1.004/ng/l; 95% CI 1.001–1.007; p = 0.036). In ROC-analysis, AUC for IL-6 was 0.98 (95% CI 0.96–0.99) for mortality, but only 0.76 (95% CI 0.68–0.84) for poor neurological outcome. The determined cut-off value for IL-6 was 431 ng/l for mortality (NPV 89.2%). In patients with IL-6 > 431 ng/l, the combination with NSE < 46 μg/l optimally identified those individuals with potential for good neurological outcome (CPC ≤ 2).ConclusionElevated IL-6 levels at admission after ROSC were closely associated with 30-day mortality. The combination of IL-6 and NSE provided clinically important additive information for predict poor neurological outcome at 6 months. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2297-055X |
| العلاقة: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.899583/fullTest; https://doaj.org/toc/2297-055XTest; https://doaj.org/article/61f2eb1cf37a4a5aa04ae679af0bdc2dTest |
| DOI: | 10.3389/fcvm.2022.899583 |
| الإتاحة: | https://doi.org/10.3389/fcvm.2022.899583Test https://doaj.org/article/61f2eb1cf37a4a5aa04ae679af0bdc2dTest |
| رقم الانضمام: | edsbas.55B5A289 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 2297055X |
|---|---|
| DOI: | 10.3389/fcvm.2022.899583 |