دورية أكاديمية
Brain metabolite levels in remitted psychotic depression with consideration of effects of antipsychotic medication
| العنوان: | Brain metabolite levels in remitted psychotic depression with consideration of effects of antipsychotic medication |
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| المؤلفون: | Tani, Hideaki, Moxon-Emre, Iska, Forde, Natalie J, Neufeld, Nicholas H, Bingham, Kathleen S, Whyte, Ellen M, Meyers, Barnett S, Alexopoulos, George S, Hoptman, Matthew J, Rothschild, Anthony J, Uchida, Hiroyuki, Flint, Alastair J, Mulsant, Benoit H, Voineskos, Aristotle N |
| المساهمون: | Psychiatry |
| المصدر: | Brain imaging and behavior ; 18 ; 1 ; 117 ; 129 ; United States ; Canada |
| سنة النشر: | 2024 |
| المجموعة: | University of Massachusetts, Medical School: eScholarship@UMMS |
| مصطلحات موضوعية: | Antipsychotics, Brain metabolites, Magnetic resonance spectroscopy, Placebo, Randomized controlled trial |
| الوصف: | Background: The neurobiology of psychotic depression is not well understood and can be confounded by antipsychotics. Magnetic resonance spectroscopy (MRS) is an ideal tool to measure brain metabolites non-invasively. We cross-sectionally assessed brain metabolites in patients with remitted psychotic depression and controls. We also longitudinally assessed the effects of olanzapine versus placebo on brain metabolites. Methods: Following remission, patients with psychotic depression were randomized to continue sertraline + olanzapine (n = 15) or switched to sertraline + placebo (n = 18), at which point they completed an MRS scan. Patients completed a second scan either 36 weeks later, relapse, or discontinuation. Where water-scaled metabolite levels were obtained and a Point-RESolved Spectroscopy sequence was utilized, choline, myo-inositol, glutamate + glutamine (Glx), N-acetylaspartate, and creatine were measured in the left dorsolateral prefrontal cortex (L-DLPFC) and dorsal anterior cingulate cortex (dACC). An ANCOVA was used to compare metabolites between patients (n = 40) and controls (n = 46). A linear mixed-model was used to compare olanzapine versus placebo groups. Results: Cross-sectionally, patients (compared to controls) had higher myo-inositol (standardized mean difference [SMD] = 0.84; 95%CI = 0.25-1.44; p = 0.005) in the dACC but not different Glx, choline, N-acetylaspartate, and creatine. Longitudinally, patients randomized to placebo (compared to olanzapine) showed a significantly greater change with a reduction of creatine (SMD = 1.51; 95%CI = 0.71-2.31; p = 0.0002) in the dACC but not glutamate + glutamine, choline, myo-inositol, and N-acetylaspartate. Conclusions: Patients with remitted psychotic depression have higher myo-inositol than controls. Olanzapine may maintain creatine levels. Future studies are needed to further disentangle the mechanisms of action of olanzapine. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1931-7565 |
| العلاقة: | Brain Imaging and Behavior; https://doi.org/10.1007/s11682-023-00807-0Test; Tani H, Moxon-Emre I, Forde NJ, Neufeld NH, Bingham KS, Whyte EM, Meyers BS, Alexopoulos GS, Hoptman MJ, Rothschild AJ, Uchida H, Flint AJ, Mulsant BH, Voineskos AN. Brain metabolite levels in remitted psychotic depression with consideration of effects of antipsychotic medication. Brain Imaging Behav. 2024 Feb;18(1):117-129. doi:10.1007/s11682-023-00807-0. Epub 2023 Nov 2. PMID: 37917311; PMCID: PMC10844359.; http://hdl.handle.net/20.500.14038/53270Test |
| DOI: | 10.1007/s11682-023-00807-0 |
| الإتاحة: | https://doi.org/10.1007/s11682-023-00807-0Test https://doi.org/20.500.14038/53270Test https://hdl.handle.net/20.500.14038/53270Test |
| حقوق: | Copyright © The Author(s) 2023. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0Test/.; Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.55A448 |
| قاعدة البيانات: | BASE |
| تدمد: | 19317565 |
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| DOI: | 10.1007/s11682-023-00807-0 |