التفاصيل البيبلوغرافية
| العنوان: |
Increased Subcortical Sodium Levels in Patients with Progressive Supranuclear Palsy |
| المؤلفون: |
Jannik Prasuhn, Martin Göttlich, Sinja S. Großer, Katharina Reuther, Britt Ebeling, Christina Bodemann, Henrike Hanssen, Armin M. Nagel, Norbert Brüggemann |
| المصدر: |
Biomedicines; Volume 10; Issue 7; Pages: 1728 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2022 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
23 Na-MRI, heteronuclear MRI, progressive supranuclear palsy, PSP, neurodegeneration |
| الوصف: |
Progressive supranuclear palsy (PSP) is a debilitating neurodegenerative disease characterized by an aggressive disease course. Total and intracellular-weighted sodium imaging (23Na-MRI) is a promising method for investigating neurodegeneration in vivo. We enrolled 10 patients with PSP and 20 age- and gender-matched healthy control subjects; all study subjects underwent a neurological examination, whole-brain structural, and (total and intracellular-weighted) 23Na-MRI. Voxel-wise analyses revealed increased brainstem total sodium content in PSP that correlated with disease severity. The ROI-wise analysis highlighted additional sodium level changes in other regions implicated in the pathophysiology of PSP. 23Na-MRI yields substantial benefits for the diagnostic workup of patients with PSP and adds complementary information on the underlying neurodegenerative tissue changes in PSP. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| العلاقة: |
Neurobiology and Neurologic Disease; https://dx.doi.org/10.3390/biomedicines10071728Test |
| DOI: |
10.3390/biomedicines10071728 |
| الإتاحة: |
https://doi.org/10.3390/biomedicines10071728Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.558ED732 |
| قاعدة البيانات: |
BASE |
