التفاصيل البيبلوغرافية
| العنوان: |
The Etiology of LVH - A Review Of Genetic Predispositions |
| المؤلفون: |
Canham, Russell M. |
| المساهمون: |
Drazner, Mark H. |
| سنة النشر: |
2006 |
| المجموعة: |
UT Southwestern Medical Center Institutional Repository (University of Texas) |
| مصطلحات موضوعية: |
Coronary Artery Disease, Cardiomyopathy, Hypertrophic, Familial, Hypertrophy, Left Ventricular |
| الوصف: |
My research fellowship was focused on assessing putative associations of polymorphisms in candidate genes with cardiovascular disease. Two previously well publicized associations were tested in the Dallas Heart Study (DHS), a stratified random population-sample of 6,101 Dallas County residents aged 18-65, with equivalent numbers of Black and non-Black women and men.1 The first putative association tested was whether two polymorphisms in adrenergic receptors (alpha 2CDel322-325 and ß1Arg389) synergistically increased the risk of heart failure in Blacks as reported by others (adjusted odds ratio, 10.1; 95% CI: 2.11 to 48.53; p=0.004).2 In the DHS, we found that these variant alleles were not associated with self-reported heart failure or traits commonly accepted to be precursors for systolic HF, including left ventricular hypertrophy, increased left ventricular volume, reduced ejection fraction, and left ventricular mass (LVM).3 The second putative association tested was whether polymorphisms in the alpha 2A-adrenergic receptor (DraI restriction fragment length protein) and the alpha 2C-adrenergic receptor (Del 322-325) increased the risk of hypertension in Blacks.4, 5 Again, we were unable to replicate these findings. We found that these variant alleles were not associated with hypertension in Blacks in the DHS, alone or in combination.6 Based on this experience, the present review was undertaken to analyze the genetic influence on a cardiovascular disease and determine whether lack of reproducibility of genetic association studies occurs commonly. Given the breadth of this topic, I have chosen to focus on association studies of putative polymorphisms with the development of the "complex" trait of left ventricular hypertrophy (LVH). LVH can be defined as increased LV mass in relation to body size. The geometric pattern of this increased LV mass in LVH is important.7 In response to pressure overload from conditions like hypertension, there is increased LV wall thickness leading to an increase in LV mass and the ... |
| نوع الوثيقة: |
doctoral or postdoctoral thesis |
| وصف الملف: |
Electronic; application/pdf; born digital |
| اللغة: |
English |
| العلاقة: |
https://hdl.handle.net/2152.5/695Test; 755069297 |
| الإتاحة: |
https://hdl.handle.net/2152.5/695Test |
| رقم الانضمام: |
edsbas.54F9C81D |
| قاعدة البيانات: |
BASE |
