التفاصيل البيبلوغرافية
| العنوان: |
Prevalence of increased QT interval duration and dispersion in type 2 diabetic patients and its relationship with coronary heart disease: a population‐based cohort |
| المؤلفون: |
VEGLIO, M., BRUNO, G., BORRA, M., MACCHIA, G., BARGERO, G., D'ERRICO, N., PAGANO, G. F., CAVALLO‐PERIN, P. |
| المصدر: |
Journal of Internal Medicine ; volume 251, issue 4, page 317-324 ; ISSN 0954-6820 1365-2796 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2002 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Veglio M, Bruno G, Borra M, Macchia G, Bargero G, D'Errico N, Pagano GF, Cavallo‐Perin P (Evangelico Valdese Hospital, Torino; University of Torino, Torino; and S. Spirito Hospital, Casale Monferrato; Italy). Prevalence of increased QT interval duration and dispersion in type 2 diabetic patients and its relationship with coronary heart disease: a population‐based cohort. J Intern Med 2002; 251: 317–324. Objective. To evaluate the prevalence of prolonged QT interval and dispersion in a population‐based cohort of type 2 diabetic patients and their relationship with clinical and metabolic variables. Design. Cross‐sectional population‐based cohort. Setting. Diabetes clinics and general practitioners in Casale Monferrato (Northern Italy). Subjects. A total of 1357 patients with known type 2 diabetes (70% of the cohort). Main outcome measures. Albumin excretion rate and coronary heart disease (CHD); a standard supine 12‐lead electrocardiogram (ECG) was recorded and coded according to the Minnesota code criteria. QT interval corrected for heart rate (QTc) > 0.44 s and QTc dispersion > 0.080 s were considered abnormally prolonged. Results. Prevalence of increased QTc duration and QTc dispersion were 25.8% (95% CI 23.5–28.3) and 33.1% (95% CI 30.6–35.7), with no sex differences. No metabolic differences were found, apart from fibrinogen and creatinine levels, which were higher in patients with increased QTc dispersion. Patients with CHD had higher mean adjusted values of QTc and QTc dispersion, whereas no association was found with albumin excretion rate (AER) and diabetes treatment. QTc duration and QTc dispersion were significantly correlated (0.17, P < 0.001). In multiple regression analysis, only CHD was independently associated with QTc, after adjustment for age and sex (β=0.010, P < 0.001, R 2 =2.5%); as regards QTc dispersion, a similar association with CHD was found (β=0.20, P < 0.001, R 2 =4.8%). Conclusions. This population‐based study shows a considerably high prevalence of increased ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1046/j.1365-2796.2002.00955.x |
| الإتاحة: |
https://doi.org/10.1046/j.1365-2796.2002.00955.xTest |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.54DB49EF |
| قاعدة البيانات: |
BASE |
