دورية أكاديمية
Novel positron emission tomography tracers for imaging vascular inflammation
| العنوان: | Novel positron emission tomography tracers for imaging vascular inflammation |
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| المؤلفون: | Corovic, A, Wall, C, Mason, JC, Rudd, JHF, Tarkin, JM |
| المصدر: | 11 ; 1 |
| بيانات النشر: | Springer |
| سنة النشر: | 2020 |
| المجموعة: | Imperial College London: Spiral |
| مصطلحات موضوعية: | Science & Technology, Life Sciences & Biomedicine, Cardiac & Cardiovascular Systems, Cardiovascular System & Cardiology, PET, Inflammation, Atherosclerosis, Large-vessel vasculitis, Molecular imaging, Non-invasive imaging, ATHEROSCLEROTIC PLAQUE INFLAMMATION, LARGE VESSEL VASCULITIS, RECEPTOR 4 EXPRESSION, TARGETING P-SELECTIN, RISK-FACTORS, NONINVASIVE ASSESSMENT, IMPROVES PREDICTION, FDG UPTAKE, MACROPHAGE, Cardiovascular System & Hematology, 1102 Cardiorespiratory Medicine and Haematology |
| الوصف: | Purpose of Review To provide a focused update on recent advances in positron emission tomography (PET) imaging in vascular inflammatory diseases and consider future directions in the field. Recent Findings While PET imaging with 18F-fluorodeoxyglucose (FDG) can provide a useful marker of disease activity in several vascular inflammatory diseases, including atherosclerosis and large-vessel vasculitis, this tracer lacks inflammatory cell specificity and is not a practical solution for imaging the coronary vasculature because of avid background myocardial signal. To overcome these limitations, research is ongoing to identify novel PET tracers that can more accurately track individual components of vascular immune responses. Use of these novel PET tracers could lead to a better understanding of underlying disease mechanisms and help inform the identification and stratification of patients for newly emerging immune-modulatory therapies. Summary Future research is needed to realise the true clinical translational value of PET imaging in vascular inflammatory diseases. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1523-3782 |
| العلاقة: | Current Cardiology Reports; http://hdl.handle.net/10044/1/87653Test |
| DOI: | 10.1007/s11886-020-01372-4 |
| الإتاحة: | https://doi.org/10.1007/s11886-020-01372-4Test http://hdl.handle.net/10044/1/87653Test |
| حقوق: | © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0Test/. ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.54C4EC43 |
| قاعدة البيانات: | BASE |
| تدمد: | 15233782 |
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| DOI: | 10.1007/s11886-020-01372-4 |