دورية أكاديمية
The Hypothesis of the Human iNKT/Innate CD8(+) T-Cell Axis Applied to Cancer: Evidence for a Deficiency in Chronic Myeloid Leukemia
| العنوان: | The Hypothesis of the Human iNKT/Innate CD8(+) T-Cell Axis Applied to Cancer: Evidence for a Deficiency in Chronic Myeloid Leukemia |
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| المؤلفون: | Jacomet, Florence, Cayssials, Emilie, Barbarin, Alice, Desmier, Déborah, Basbous, Sara, Lefèvre, Lucie, Levescot, Anaïs, Robin, Aurélie, Piccirilli, Nathalie, Giraud, Christine, Guilhot, François, Roy, Lydia, Herbelin, André, Gombert, Jean-Marc |
| المساهمون: | Ischémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques U 1082 ( IRTOMIT Poitiers ), Université de Poitiers = University of Poitiers (UP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Immunologie et Inflammation Poitiers, Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie ), Service d'Hématologie CHU Poitiers, Agronomie, Institut National de la Recherche Agronomique (INRA)-AgroParisTech, INSERM CIC 0802 (INSERM - CHU de Poitiers), Université de Poitiers = University of Poitiers (UP)-Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie )-Institut National de la Santé et de la Recherche Médicale (INSERM), Etablissement Français du Sang Centre-Atlantique, CIC Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402), Université de Poitiers = University of Poitiers (UP)-Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie )-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service Clinique d'Hématologie Créteil, Hôpital Henri Mondor, Communauté Université Paris-Est, Université Paris Descartes - Paris 5 (UPD5), This study was supported by INSERM, CHU de Poitiers, Université de Poitiers, Ligue contre le Cancer du Grand Ouest (Comités départementaux de la Vienne, de la Charente, de la Charente Maritime et des Deux-Sèvres), Association pour la Recherche en Immunologie-Poitou-Charentes (ARIM-PC), Association Laurette Fugain, Ministère de la Recherche, Sport & Collection, and INCa-DGOS 8658 (PRT-K 2015-052). |
| المصدر: | ISSN: 1664-3224. |
| بيانات النشر: | HAL CCSD Frontiers |
| سنة النشر: | 2017 |
| المجموعة: | Université de Poitiers: Publications de nos chercheurs.ses (HAL) |
| مصطلحات موضوعية: | NK-like CD8(+) T cells, chronic myeloid leukemia, iNKT cells, innate CD8(+) T cells, tyrosine kinase inhibitor, [SDV.IMM]Life Sciences [q-bio]/Immunology, [SDV.CAN]Life Sciences [q-bio]/Cancer |
| الوصف: | International audience ; We recently identified a new human subset of NK-like [KIR/NKG2A(+)] CD8(+) T cells with a marked/memory phenotype, high Eomesodermin expression, potent antigen-independent cytotoxic activity, and the capacity to generate IFN-γ rapidly after exposure to pro-inflammatory cytokines. These features support the hypothesis that this new member of the innate T cell family in humans, hereafter referred to as innate CD8(+) T cells, has a role in cancer immune surveillance analogous to invariant natural killer T (iNKT) cells. Here, we report the first quantitative and functional analysis of innate CD8(+) T cells in a physiopathological context in humans, namely chronic myeloid leukemia (CML), a well-characterized myeloproliferative disorder. We have chosen CML based on our previous report that IL-4 production by iNKT cells was deficient in CML patients at diagnosis and considering the recent evidence in mice that IL-4 promotes the generation/differentiation of innate CD8(+) T cells. We found that the pool of innate CD8(+) T cells was severely reduced in the blood of CML patients at diagnosis. Moreover, like iNKT and NK cells, innate CD8(+) T cells were functionally impaired, as attested by their loss of antigen-independent cytotoxic activity and IFN-γ production in response to innate-like stimulation with IL-12 + IL-18. Remarkably, as previously reported for IL-4 production by iNKT cells, both quantitative and functional deficiencies of innate CD8(+) T cells were at least partially corrected in patients having achieved complete cytogenetic remission following tyrosine kinase inhibitor therapy. Finally, direct correlation between the functional potential of innate CD8(+) T and iNKT cells was found when considering all healthy donors and CML patients in diagnosis and remission, in accordance with the iNKT cell-dependent generation of innate CD8(+) T cells reported in mice. All in all, our data demonstrate that CML is associated with deficiencies of innate CD8(+) T cells that are restored upon ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/28138330; inserm-02508027; https://inserm.hal.science/inserm-02508027Test; https://inserm.hal.science/inserm-02508027/documentTest; https://inserm.hal.science/inserm-02508027/file/fimmu-07-00688.pdfTest; PUBMED: 28138330; PUBMEDCENTRAL: PMC5237805 |
| DOI: | 10.3389/fimmu.2016.00688 |
| الإتاحة: | https://doi.org/10.3389/fimmu.2016.00688Test https://inserm.hal.science/inserm-02508027Test https://inserm.hal.science/inserm-02508027/documentTest https://inserm.hal.science/inserm-02508027/file/fimmu-07-00688.pdfTest |
| حقوق: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.54B4BF90 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fimmu.2016.00688 |
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