رسالة جامعية
Nh-pirazóis e isoxazóis: síntese mecanicamente ativada por grinding ; Nh-pyrazoles and isoxazoles: synthesis mechanically activated by grinding
| العنوان: | Nh-pirazóis e isoxazóis: síntese mecanicamente ativada por grinding ; Nh-pyrazoles and isoxazoles: synthesis mechanically activated by grinding |
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| المؤلفون: | Longhi, Kelvis |
| المساهمون: | Martins, Marcos Antonio Pinto, http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4783192P3Test, Rodrigues, Oscar Endrigo Dorneles, http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4763956Z6Test, Siqueira, Geonir Machado, http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4782774H9Test |
| بيانات النشر: | Universidade Federal de Santa Maria BR Química UFSM Programa de Pós-Graduação em Química |
| سنة النشر: | 2010 |
| المجموعة: | Manancial - Repositório Digital da UFSM (Universidade Federal de Santa Maria) |
| مصطلحات موضوعية: | Enaminonas, Pirazóis, Isoxazóis, Condições sem solvente, Grinding, Enaminones, Pyrazoles, Isoxazoles, Solvent-free conditions, CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
| الوصف: | The synthesis of twelve NH-pyrazoles from the cyclocondensation reaction of β-dimethylaminovinylketones ([R1C(O)C(R2)=CHN(Me)2], where R1 = Me, C6H5, 3- MeO-C6H4, 4-Me-C6H4, 4-MeO-C6H4, 4-F-C6H4, 4-Cl-C6H4, 4-Br-C6H4, 4-O2N-C6H4, fur-2-il, tien-2-il; R2 = H, 2-MeO-C6H4 and R1, R2 = -(CH2)3C(O)- with hydrazine sulfate is reported. In this work, it was also demonstrated the synthesis of twelve isoxazoles from the cyclocondensation reaction of β-dimethylaminovinylketones where R1 = Me, C6H5, 3-MeO-C6H4, 4-Me-C6H4, 4-MeO-C6H4, 4-F-C6H4, 4-Cl-C6H4, 4-Br-C6H4, 4-biphenyl, naphthalen-2-yl, 4-O2N-C6H4, thien-2-yl and R2 = H, 2-MeOC6H4 with hydroxylamine hydrochloride. The reactions were performed in the presence of p-toluene sulfonic acid as the catalyst through two methodologies: (i) by the solvent-free grinding method, and (ii) using the conventional method, ethanol reflux. In addition, the Grindstone Chemistry methodology demonstrated that largescale synthesis is also possible. Making a comparison with the classical reaction conditions, which employ molecular solvent (ethanol), the grinding method has as main advantages of shorter reaction time (5-15 min), higher product yields (60-92%), mild reaction conditions as well as being environmentally friendly. ; Conselho Nacional de Desenvolvimento Científico e Tecnológico ; Neste trabalho é descrita a síntese de uma série de doze NH-pirazóis a partir da reação de ciclocondensação de β-dimetilaminovinilcetonas ([R1C(O)C(R2)=CHN(Me)2], onde R1 = Me, C6H5, 3-MeO-C6H4, 4-Me-C6H4, 4-MeOC6H4, 4-F-C6H4, 4-Cl-C6H4, 4-Br-C6H4, 4-O2N-C6H4, fur-2-il, tien-2-il; R2 = H, 2-MeOC6H4 e R1, R2 = -(CH2)3C(O)- com sulfato de hidrazina. Também foi realizada a síntese de uma série de doze isoxazóis a partir da reação de ciclocondensação de β-enamino cetonas, onde R1 = Me, C6H5, 3-MeO-C6H4, 4-Me-C6H4, 4-MeO-C6H4, 4- F-C6H4, 4-Cl-C6H4, 4-Br-C6H4, 4-bifenil, naft-2-il, 4-O2N-C6H4, tien-2-il e R2 = H, 2-MeO-C6H4 com cloridrato de hidroxilamina. As reações para obtenção dos compostos ... |
| نوع الوثيقة: | thesis |
| وصف الملف: | application/pdf |
| اللغة: | Portuguese |
| العلاقة: | LONGHI, Kelvis. Nh-pyrazoles and isoxazoles: synthesis mechanically activated by grinding. 2010. 168 f. Dissertação (Mestrado em Química) - Universidade Federal de Santa Maria, Santa Maria, 2010.; http://repositorio.ufsm.br/handle/1/10474Test |
| الإتاحة: | http://repositorio.ufsm.br/handle/1/10474Test |
| حقوق: | Acesso Aberto |
| رقم الانضمام: | edsbas.546E91A3 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |