التفاصيل البيبلوغرافية
| العنوان: |
CD4+ T cell heterogeneity in gestational age and preeclampsia using single-cell RNA sequencing |
| المؤلفون: |
Tsuda, Sayaka, Shichino, Shigeyuki, Tilburgs, Tamara, Shima, Tomoko, Morita, Keiko, Yamaki-Ushijima, Akemi, Roskin, Krishna, Tomura, Michio, Sameshima, Azusa, Saito, Shigeru, Nakashima, Akitoshi |
| المصدر: |
Frontiers in Immunology ; volume 15 ; ISSN 1664-3224 |
| بيانات النشر: |
Frontiers Media SA |
| سنة النشر: |
2024 |
| المجموعة: |
Frontiers (Publisher - via CrossRef) |
| الوصف: |
A balance between pro-inflammatory decidual CD4 + T cells and FOXP3 + regulatory T cells ( FOXP3 + Tregs) is important for maintaining fetomaternal tolerance. Using single-cell RNA-sequencing and T cell receptor repertoire analysis, we determined that diversity and clonality of decidual CD4 + T cell subsets depend on gestational age. Th1/Th2 intermediate and Th1 subsets of CD4 + T cells were clonally expanded in both early and late gestation, whereas FOXP3 + Tregs were clonally expanded in late gestation. Th1/Th2 intermediate and FOXP3 + Treg subsets showed altered gene expression in preeclampsia (PE) compared to healthy late gestation. The Th1/Th2 intermediate subset exhibited elevated levels of cytotoxicity-related gene expression in PE. Moreover, increased Treg exhaustion was observed in the PE group, and FOXP3 + Treg subcluster analysis revealed that the effector Treg like subset drove the Treg exhaustion signatures in PE. The Th1/Th2 intermediate and effector Treg like subsets are possible inflammation-driving subsets in PE. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| DOI: |
10.3389/fimmu.2024.1401738 |
| DOI: |
10.3389/fimmu.2024.1401738/full |
| الإتاحة: |
https://doi.org/10.3389/fimmu.2024.1401738Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.546A4C4A |
| قاعدة البيانات: |
BASE |
