دورية أكاديمية
The human myotubularin-related protein suppresses the growth of lung carcinoma cells
| العنوان: | The human myotubularin-related protein suppresses the growth of lung carcinoma cells |
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| المساهمون: | Young Do Yoo, Sun Mi Cho, Hyung Jung Kim, Chul Min Ahn, Yoon Soo Chang, Jun Suk Kim, Kim, Hyung Jung, Ahn, Chul Min, Chang, Yoon Soo |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Blotting, Northern, Cell Cycle, Cell Cycle Proteins/metabolism, Cell Differentiation, Cell Division, Cell Line, Tumor, Cell Separation, Cyclin-Dependent Kinase Inhibitor p27, DNA/chemistry, DNA, Complementary/metabolism, Dose-Response Relationship, Drug, Flow Cytometry, G1 Phase, Genetic Therapy/methods, Genetic Vectors, Humans, Immunoblotting, Lung Neoplasms/metabolism, Lung Neoplasms/therapy, Protein Tyrosine Phosphatases/genetics, Protein Tyrosine Phosphatases/physiology, Protein Tyrosine Phosphatases, Non-Receptor, Transfection, Treatment Outcome, Tumor Suppressor Proteins/metabolism |
| الوصف: | Herein, we report that the human myotubularin-related protein (KIAA0371) induced growth suppression of lung cancer cells. Colony formation assays demonstrated that the exogenous expression of the human myotubularin-related gene induced a significant growth inhibition of H1299 cells in which the expression of the human myotubularin-related gene was undetectable. Colony formation of these cells was reduced by 39% after transfection with this gene, as compared with the control vector. Cells stably transfected with this gene showed a reduction in growth of 48% compared with those cells transfected with the empty vector. We also showed that this negative regulation of the myotubularin-related protein is correlated with cell-cycle arrest at G1. In addition, we found that the cyclin-dependent kinase inhibitor, p27, is induced by increased expression of the human myotubularin-related gene. These results suggest that the human myotubularin-related protein can negatively regulate the growth of lung cancer cells. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 1021-335X 1791-2431 |
| العلاقة: | ONCOLOGY REPORTS; J02419; OAK-2004-01155; https://ir.ymlib.yonsei.ac.kr/handle/22282913/111734Test; http://www.spandidos-publications.com/or/12/3/667Test; T200401392; ONCOLOGY REPORTS, Vol.12(3) : 667-671, 2004 |
| DOI: | 10.3892/or.12.3.667 |
| الإتاحة: | https://doi.org/10.3892/or.12.3.667Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/111734Test http://www.spandidos-publications.com/or/12/3/667Test |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ ; not free |
| رقم الانضمام: | edsbas.5446E2A2 |
| قاعدة البيانات: | BASE |
| تدمد: | 1021335X 17912431 |
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| DOI: | 10.3892/or.12.3.667 |