التفاصيل البيبلوغرافية
| العنوان: |
Neutralizing antibodies against SARS-CoV-2 in Brazilian pregnant women vaccinated with one or two doses of BNT162b2 mRNA vaccine (Pfizer/WyethTM) |
| المؤلفون: |
Silva, Mauro César da, Silva, Neila Caroline Henrique da, Ferreira, Ana Laura Carneiro Gomes, Ferreira, Fernanda Carneiro Gomes, Melo, Maria Inês Bezerra de, Silva, Letícia Micherlyne Xavier da, Barbosa, Camila Rodrigues de Melo, Magalhães, Jurandy Júnior Ferraz de, Diniz, George Tadeu Nunes, Souza, Ariani Impieri, Lucena-Silva, Norma |
| المساهمون: |
Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco, Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| المصدر: |
Frontiers in Public Health ; volume 10 ; ISSN 2296-2565 |
| بيانات النشر: |
Frontiers Media SA |
| سنة النشر: |
2023 |
| المجموعة: |
Frontiers (Publisher - via CrossRef) |
| مصطلحات موضوعية: |
Public Health, Environmental and Occupational Health |
| الوصف: |
Pregnant women have an increased risk of developing severe coronavirus disease. In Brazil, the number of hospitalizations and adverse outcomes, including death caused by COVID-19, in women during the pregnancy-puerperal cycle was high in the first pandemic year. Doubts regarding vaccines' efficacy and safety for the mother and fetus delayed vaccination. This study evaluated the generation of IgG titers and neutralizing antibodies to the BNT162b2 mRNA vaccine in 209 healthy pregnant women. For this, were used the QuantiVac ELISA (IgG) and SARS-CoV-2 NeutraLISA kits (EUROIMMUN, Lübeck, SH) following the manufacturer's recommendations. One dose vaccine produced anti-SARS-CoV-2 IgG in 85% (81/95), and two produced in 95% (76/80) women. Among unvaccinated women, four of 34 (12%) showed protection. The first dose of the BNT162b2 vaccine protected 69% of the women with neutralizing antibodies (median of %IH = 97). In the second dose, protection occurred in 94% of the pregnant women (median of IH% = 97). This study showed no differences in IgG antibody titers between one- and two-dose of the BNT162b2 mRNA vaccine groups, boosting with the second dose increased the number of women who produced specific IgG and neutralizing antibodies, raising by 114-folds the chance of producing the SARS-CoV-2 neutralizing antibodies compared to the unvaccinated pregnant woman, which may contribute to reduce the chance of severe COVID-19. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| DOI: |
10.3389/fpubh.2022.1054460 |
| DOI: |
10.3389/fpubh.2022.1054460/full |
| الإتاحة: |
https://doi.org/10.3389/fpubh.2022.1054460Test |
| حقوق: |
https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.5426F961 |
| قاعدة البيانات: |
BASE |
