دورية أكاديمية
Coronary volume to left ventricular mass ratio in patients with diabetes mellitus
| العنوان: | Coronary volume to left ventricular mass ratio in patients with diabetes mellitus |
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| المؤلفون: | Kuneman, J.H., Mahdiui, M. el, Rosendael, A.R. van, Hoogen, I.J. van den, Patel, M.R., Norgaard, B.L., Fairbairn, T.A., Nieman, K., Akasaka, T., Berman, D.S., Koweek, L.M.H., Pontone, G., Kawasaki, T., Sand, N.P.R., Jensen, J.M., Amano, T., Poon, M., Ovrehus, K.A., Sonck, J., Rabbat, M.G., Bruyne, B. de, Rogers, C., Matsuo, H., Bax, J.J., Leipsic, J.A., Knuuti, J. |
| المصدر: | Journal of Cardiovascular Computed Tomography |
| سنة النشر: | 2022 |
| المجموعة: | Leiden Repository (Leiden University) |
| مصطلحات موضوعية: | Coronary volume, Left ventricular mass, Volume to mass ratio, Coronary computed tomography angiography, Coronary artery disease, Diabetes mellitus |
| الوصف: | Background: Diabetes mellitus is a major risk factor for coronary artery disease (CAD) and may provoke structural and functional changes in coronary vasculature. The coronary volume to left ventricular mass (V/M) ratio is a new anatomical parameter capable of revealing a potential physiological imbalance between coronary vasculature and myocardial mass. The aim of this study was to examine the V/M derived from coronary computed tomography angiography (CCTA) in patients with diabetes. Methods: Patients with clinically suspected CAD enrolled in the ADVANCE (Assessing Diagnostic Value of Non-invasive FFRCT in Coronary Care) registry and known diabetic status were included. Coronary artery volume and left ventricular myocardial mass were analyzed from CCTA and the V/M ratio was calculated and compared between patients with and without diabetes. Results: Of the 3053 patients (age 66 +/- 10 years; 66% male) with known diabetic status, diabetes was present in 21.9%. Coronary volume was lower in patients with diabetes compared to those without diabetes (2850 +/- 940 mm(3) vs. 3040 +/- 970 mm(3), p < 0.0001), whereas the myocardial mass was comparable between the 2 groups (122 +/- 33 g vs. 122 +/- 32 g, p = 0.70). The V/M ratio was significantly lower in patients with diabetes (23.9 +/- 6.8 mm(3)/g vs. 25.7 +/- 7.5 mm(3)/g, p < 0.0001). Among subjects with obstructive CAD (n = 2191, 24.0% diabetics) and non-obstructive CAD (16.7% diabetics), the V/M ratio was significantly lower in patients with diabetes compared to those without (23.4 +/- 6.7 mm(3)/g vs. 25.0 +/- 7.3 mm(3)/g, p < 0.0001 and 25.6 +/- 6.9 mm(3)/g vs. 27.3 +/- 7.6 mm(3)/g, respectively, p = 0.006). Conclusion: The V/M ratio was significantly lower in patients with diabetes compared to non-diabetics, even after correcting for obstructive coronary stenosis. The clinical value of the reduced V/M ratio in diabetic patients needs further investigation. ; Cardiology |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | lumc-id: 177688743; https://hdl.handle.net/1887/3567763Test |
| DOI: | 10.1016/j.jcct.2022.01.004 |
| الإتاحة: | https://doi.org/10.1016/j.jcct.2022.01.004Test https://hdl.handle.net/1887/3567763Test |
| رقم الانضمام: | edsbas.53B9237A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jcct.2022.01.004 |
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