دورية أكاديمية
Impact of the number of modifiable risk factors on clinical outcomes after percutaneous coronary intervention: An analysis from the e-Ultimaster registry.
| العنوان: | Impact of the number of modifiable risk factors on clinical outcomes after percutaneous coronary intervention: An analysis from the e-Ultimaster registry. |
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| المؤلفون: | Kobo, Ofer, Levi, Yaniv, Abu-Fanne, Rami, Von Birgelen, Clemens, Guédès, Antoine, Aminian, Adel, Laanmets, Peep, Dewilde, Willem, Witkowski, Adam, Monsegu, Jacques, Romo Iniguez, Andres, Halabi, Majdi, Mamas, Mamas A, Roguin, Ariel |
| المساهمون: | UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (MGD) Service de cardiologie |
| المصدر: | International journal of cardiology. Heart & vasculature, Vol. 51, p. 101370 (2024) |
| سنة النشر: | 2024 |
| المجموعة: | DIAL@USL-B (Université Saint-Louis, Bruxelles) |
| مصطلحات موضوعية: | Clinical trial, Drug eluting stent, Human, Percutaneous coronary intervention, Risk factor |
| الوصف: | A substantial proportion of the patients undergoing percutaneous coronary intervention (PCI) have none of the of standard modifiable cardiovascular risk factors (SMuRFs): hypertension, diabetes, hypercholesterolaemia and smoking. The aim of this analysis was to compare clinical outcomes after PCI according to the number of SMuRFs. Patients with an indication for a PCI were stratified based upon the number of SMuRFs: 0, 1, 2 or 3-4. The primary outcome was target lesion failure (TLF), a composite of cardiac death, target vessel-related myocardial infarction or clinically driven target lesion revascularization at 1-year. Inverse weighted propensity score (IWPS) adjustment was performed to adjust for differences in baseline characteristics. The prevalence of SMuRFs was: 0 SMuRF 16.4 %; 1 SMuRF 27.8 %; 2 SMuRFs 34.7 % and 3-4 SMuRFs 21.1 %. Patients without SMuRFs were younger, more likely to be male and had less complex coronary artery disease. The incidence of TLF increased with the number of SMuRFs: 2.65 %, 2.75 %, 3.23 %, and 4.24 %, P < 0.001. The relative risk (RR) for a TLF was 60 % higher (95 % confidence interval 1.32-1.93, p < 0.01) for patients with 3-4 SMuRFs compared to patients without SMuRFs. The trend remained (P < 0.01) after IWPS with TLF rates of 2.88 %, 2.64 %, 2.88 % and 3.65 %. The RR for a TLF was 27 % higher (95 % CI 1.05-1.53, p < 0.01). The incidence of clinical events at 1-year increased with the number of SMuRFs. While patients without SMuRFs have a relatively favourable risk profile, more research is needed to optimize therapeutic management in the majority of patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2352-9067 |
| العلاقة: | boreal:287089; http://hdl.handle.net/2078.1/287089Test; info:pmid/38628296; urn:ISSN:2352-9067 |
| DOI: | 10.1016/j.ijcha.2024.101370 |
| الإتاحة: | https://doi.org/10.1016/j.ijcha.2024.101370Test http://hdl.handle.net/2078.1/287089Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.539E2BCA |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23529067 |
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| DOI: | 10.1016/j.ijcha.2024.101370 |