دورية أكاديمية
Gut microbiome in patients with obstructive sleep apnoea
| العنوان: | Gut microbiome in patients with obstructive sleep apnoea |
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| المؤلفون: | Bikov, András, Szabó, Helga, Piroska, Marton, Kunos, László, Szily, Marcell, Ligeti, Balázs, Makra, Nóra, Szabó, Dóra, Tárnoki, Dávid László, Tárnoki, Ádám Domonkos |
| بيانات النشر: | MDPI |
| سنة النشر: | 2022 |
| المجموعة: | MTAK: REAL (Library and Information Centre of the Hungarian Academy of Sciences / Magyar Tudományos Akadémia Könyvtár és Információs Központ) |
| مصطلحات موضوعية: | R1 Medicine (General) / orvostudomány általában |
| الوصف: | Background: Obstructive sleep apnoea (OSA) is a risk factor for cardiovascular disease. Alterations in the gut microbiome have been implicated in the development of cardiovascular disease and may potentially link OSA to its cardiovascular consequences. However, only one study to date has investigated gut microbiomes in adult patients with OSA. Methods: 19 patients with OSA and 20 non-OSA controls participated in the study. Following a diagnostic sleep study, blood was collected for metabolic profiling, and the subjects provided a stool sample for microbiome analysis. The gut microbiome was investigated using the 16S ribosomal RNA method. Results: Patients with OSA had a higher relative abundance of the Proteobacteria phylum (p = 0.03), Gammaproteobacteria class (p = 0.01), Lactobacillae family (p = 0.02), Lactobacillus (p = 0.03), and Roseburia genus (p = 0.03), and a lower abundance of the Actinobacteria phylum (p = 0.03). The abundance of Proteobacteria, Gammaproteobacteria, Lactobacillae, and Lactobacillus were related to disease severity and dyslipidaemia (all p < 0.05), whilst the abundance of Proteobacteria and Gammaproteobacteria was also related to hypertension and cardiovascular disease (all p < 0.05). However, following adjustment for relevant confounders only the association between OSA and Actinobacteria remained significant (p = 0.04). Conclusions: Obstructive sleep apnoea is associated with only subtle changes in gut microbiome. Further studies should investigate gut dysbiosis in OSA. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | http://real.mtak.hu/150545/1/applsci-12-02007.pdfTest; Bikov, András and Szabó, Helga and Piroska, Marton and Kunos, László and Szily, Marcell and Ligeti, Balázs and Makra, Nóra and Szabó, Dóra and Tárnoki, Dávid László and Tárnoki, Ádám Domonkos (2022) Gut microbiome in patients with obstructive sleep apnoea. APPLIED SCIENCES, 12 (4). No.-2007. ISSN 2076-3417 |
| DOI: | 10.3390/app12042007 |
| الإتاحة: | https://doi.org/10.3390/app12042007Test http://real.mtak.hu/150545Test/ http://real.mtak.hu/150545/1/applsci-12-02007.pdfTest |
| حقوق: | cc_by |
| رقم الانضمام: | edsbas.5392116C |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/app12042007 |
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