دورية أكاديمية
A high-fat diet induces changes in mesenteric adipose tissue accelerating early-stage pancreatic carcinogenesis in mice.
| العنوان: | A high-fat diet induces changes in mesenteric adipose tissue accelerating early-stage pancreatic carcinogenesis in mice. |
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| المؤلفون: | Ead, Aya S, Wirkus, Joanna, Matsukuma, Karen, Mackenzie, Gerardo G |
| المصدر: | J Nutr Biochem ; ISSN:1873-4847 |
| بيانات النشر: | Elsevier Science |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | Diet, fat, lipids, obesity, pancreatic cancer, pancreatic cancer risk |
| الوصف: | Increased adiposity is a significant risk factor for pancreatic cancer development. Multiple preclinical studies have documented that high-fat, high caloric diets, rich in omega-6 fatty acids (FA) accelerate pancreatic cancer development. However, the effect of a high-fat, low sucrose diet (HFD), on pancreatic carcinogenesis remains unclear. We evaluated the impact of a HFD on early-stage pancreatic carcinogenesis in the clinically relevant KrasLSL-G12D/+; Ptf1aCre/+ (KC) genetically engineered mouse model, and characterized the role of the mesenteric adipose tissue (MAT). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1016/j.jnutbio.2024.109690Test; https://pubmed.ncbi.nlm.nih.gov/38876394Test |
| DOI: | 10.1016/j.jnutbio.2024.109690 |
| الإتاحة: | https://doi.org/10.1016/j.jnutbio.2024.109690Test https://pubmed.ncbi.nlm.nih.gov/38876394Test |
| حقوق: | Copyright © 2024. Published by Elsevier Inc. |
| رقم الانضمام: | edsbas.5380E428 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jnutbio.2024.109690 |
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