دورية أكاديمية
A five-gene molecular grade index and HOXB13:IL17BR are complementary prognostic factors in early stage breast cancer.
| العنوان: | A five-gene molecular grade index and HOXB13:IL17BR are complementary prognostic factors in early stage breast cancer. |
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| المؤلفون: | Ma, Xiao-Jun, Salunga, Ranelle, Dahiya, Sonika, Wang, Wilson, Carney, Erin, Durbecq, Virginie, Harris, Adrian, Goss, Paul, Sotiriou, Christos, Erlander, Mark, Sgroi, Dennis |
| المصدر: | Clinical cancer research, 14 (9 |
| سنة النشر: | 2008 |
| المجموعة: | DI-fusion : dépôt institutionnel de l'Université libre de Bruxelles (ULB) |
| مصطلحات موضوعية: | Cancérologie, Sciences bio-médicales et agricoles, Autoantigens -- genetics, Breast Neoplasms -- diagnosis, Breast Neoplasms -- genetics, Breast Neoplasms -- mortality, Breast Neoplasms -- pathology, Chromosomal Proteins, Non-Histone -- genetics, Cohort Studies, Gene Expression Profiling, Genes, Neoplasm, Homeodomain Proteins -- genetics, Humans, Kaplan-Meiers Estimate, Prognosis, Proportional Hazards Models, Protein-Serine-Threonine Kinases -- genetics, Receptors, Interleukin -- genetics, Ribonucleoside Diphosphate Reductase -- genetics |
| الوصف: | PURPOSE: Histologic tumor grade is a well-established prognostic factor for breast cancer, and tumor grade-associated genes are the common denominator of many prognostic gene signatures. The objectives of this study are as follows: (a) to develop a simple gene expression index for tumor grade (molecular grade index or MGI), and (b) to determine whether MGI and our previously described HOXB13:IL17BR index together provide improved prognostic information. EXPERIMENTAL DESIGN: From our previously published list of genes whose expression correlates with both tumor grade and tumor stage progression, we selected five cell cycle-related genes to build MGI and evaluated MGI in two publicly available microarray data sets totaling 410 patients. Using two additional cohorts (n = 323), we developed a real-time reverse transcription PCR assay for MGI, validated its prognostic utility, and examined its interaction with HOXB13:IL17BR. RESULTS: MGI performed consistently as a strong prognostic factor and was comparable with a more complex 97-gene genomic grade index in multiple data sets. In patients treated with endocrine therapy, MGI and HOXB13:IL17BR modified each other's prognostic performance. High MGI was associated with significantly worse outcome only in combination with high HOXB13:IL17BR, and likewise, high HOXB13:IL17BR was significantly associated with poor outcome only in combination with high MGI. CONCLUSIONS: We developed and validated a five-gene reverse transcription PCR assay for MGI suitable for analyzing routine formalin-fixed paraffin-embedded clinical samples. The combination of MGI and HOXB13:IL17BR outperforms either alone and identifies a subgroup ( approximately 30%) of early stage estrogen receptor-positive breast cancer patients with very poor outcome despite endocrine therapy. ; Journal Article ; Research Support, N.I.H. Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Validation Studies ; info:eu-repo/semantics/published |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 2 full-text file(s): application/pdf | application/pdf |
| اللغة: | English |
| ردمك: | 978-5-204-90950-2 5-204-90950-8 |
| العلاقة: | uri/info:doi/10.1158/1078-0432.CCR-07-5026; uri/info:pii/14/9/2601; uri/info:pmid/18451222; uri/info:scp/52049095087; https://dipot.ulb.ac.be/dspace/bitstream/2013/54577/1/67.ClinCancerRes-Ma-2008.pdfTest; https://dipot.ulb.ac.be/dspace/bitstream/2013/54577/4/doi_30074.pdfTest; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/54577Test |
| الإتاحة: | http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/54577Test https://dipot.ulb.ac.be/dspace/bitstream/2013/54577/1/67.ClinCancerRes-Ma-2008.pdfTest |
| رقم الانضمام: | edsbas.52CE237E |
| قاعدة البيانات: | BASE |
| ردمك: | 9785204909502 5204909508 |
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