دورية أكاديمية
Effects of Mimosa caesalpiniifolia pre-formulation on the intestinal barrier during sodium dextran sulfate-induced colitis in Wistar rats ; Efectos de la preformulación de Mimosa caesalpiniifolia sobre la barrera intestinal durante la colitis inducida por sulfato de dextrano sódico en ratas Wistar
| العنوان: | Effects of Mimosa caesalpiniifolia pre-formulation on the intestinal barrier during sodium dextran sulfate-induced colitis in Wistar rats ; Efectos de la preformulación de Mimosa caesalpiniifolia sobre la barrera intestinal durante la colitis inducida por sulfato de dextrano sódico en ratas Wistar |
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| المؤلفون: | Garnevi-Fávero , Aline, Nascimento-da Silva , Karina, Rodrigues-Ribeiro , Willian, Marcantonio-Ferreira , Caroline, Sartorelli, Patrícia, Cardili, Leonardo, de Cássia-Sinigaglia , Rita, Bertaglia-Pereira, Joice Naiara, Aparecido-da Silva , Marcelo, Vilegas, Wagner, Dias- Silva, Marcelo José, Ribeiro-Paiotti , Ana Paula |
| المصدر: | Biomedica; Vol. 43 No. 2 (2023); 282-295 ; Biomédica; Vol. 43 Núm. 2 (2023); 282-295 ; 2590-7379 ; 0120-4157 |
| بيانات النشر: | Instituto Nacional de Salud |
| سنة النشر: | 2023 |
| المجموعة: | Biomédica - Revista del Instituto Nacional de Salud, Bogotá |
| مصطلحات موضوعية: | Mimosa, colitis, ulcerative, inflammatory bowel diseases, herbal medicine, colitis ulcerosa, enfermedades inflamatorias del intestino, medicina de hierbas |
| الوصف: | Introduction. Anti-inflammatories, immunosuppressants, and immunobiological are commonly used in the treatment of inflammatory bowel disease. However, some patients do not present an adequate response or lose effective response during the treatment. A recent study found a potential anti-inflammatory effect of the hydroalcoholic extract of Mimosa caesalpiniifolia on trinitrobenzene sulfonic acid-induced colitis in Wistar rats. Objective. To evaluate the effects of M. caesalpiniifolia pre-formulation on the intestinal barrier using dextran sulfate sodium-induced colitis model.Materials and methods. Leaf extracts were prepared in 70% ethanol and dried with a Buchi B19 Mini-spray dryer using 20% Aerosil® solution. Thirty-two male Wistar ratswere randomized into four groups: basal control, untreated colitis, pre-formulation control (125 mg/kg/day), and colitis treated with pre-formulation (125 mg/kg/day). Clinical activity index was recorded daily and all rats were euthanized on the ninth day. Colon fragments were fixed and processed for histological and ultrastructural analyses. Stool samples were collected and processed for analysis of the short-chain fatty acid.Results. Treatment with the pre-formulation decreased the clinical activity (bloody diarrhea), inflammatory infiltrate, and the ulcers. Pre-formulation did not repair the epithelial barrier and there were no significant differences in the goblet cells index. There was a significant difference in butyrate levels in the rats treated with the pre-formulation. Conclusions. The pre-formulation minimized the clinical symptoms of colitis and intestinal inflammation, but did not minimize damage to the intestinal barrier. ; Introducción. Los antiinflamatorios, inmunosupresores e inmunobiológicos se utilizan comúnmente para tratar la enfermedad intestinal inflamatoria. Sin embargo, algunos pacientes no presentan una respuesta adecuada o pierden respuesta efectiva durante el tratamiento. En un estudio reciente, se encontró un potencial efecto antiinflamatorio del ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf; text/xml |
| اللغة: | English |
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| الإتاحة: | https://doi.org/10.5217/ir.2015.13.1.19Test https://doi.org/10.1053/j.gastro.2019.04.016Test https://doi.org/10.1152/ajpgi.90516.2008Test https://doi.org/10.1590/1414-431X20143774Test https://doi.org/10.1016/j.semcdb.2014.08.011Test https://doi.org/10.1177/1756283X09102329Test https://doi.org/10.1590/S1516-05722012000300001Test https://doi.org/10.1016/j.jep.2013.03.075Test https://doi.org/10.1016/j.sajb.2014.03.011Test https://doi.org/10.1055/s-0034-1394688Test |
| حقوق: | Derechos de autor 2023 Biomédica ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.5298F33A |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |