دورية أكاديمية
Plasma IL-5 but Not CXCL13 Correlates With Neutralization Breadth in HIV-Infected Children
| العنوان: | Plasma IL-5 but Not CXCL13 Correlates With Neutralization Breadth in HIV-Infected Children |
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| المؤلفون: | Roider, J, Zachary Porterfield, J, Ogongo, P, Muenchhoff, M, Adland, E, Groll, A, Morris, L, Moore, PL, Ndung'U, T, Kløverpris, H, Goulder, PJR, Leslie, A |
| المصدر: | Frontiers in Immunology , 10 , Article 1497. (2019) |
| سنة النشر: | 2019 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | CXCL13, IL-5, Activin A, broadly neutralizing antibodies (bnAbs), pediatric HIV, plasma markers, HIV neutralization breadth, T-follicular helper cells (Tfh) |
| الوصف: | Children may be the optimal target for HIV vaccine development as they generate substantially more frequent and more potent broadly HIV neutralizing antibodies (bnAbs) than adults. Development of a biomarker that correlates with neutralization breadth in this group could function as a powerful tool to facilitate the development of an HIV vaccine. Previously, we observed that this preferential ability in HIV-infected children over adults to generate bnAbs is associated with an enrichment of circulating follicular helper T-cells (TFH) with an effector phenotype, and the presence of IL-21 secreting HIV-specific TFH within lymphoid tissue germinal centers (GC). In adults, bnAbs development has been linked with high plasma levels of CXCL13, a chemoattractant for CXCR5-expressing TFH cells to the lymph node GC. We sought to test this relationship in HIV-infected children, but found no association between neutralization breadth and plasma levels of CXCL13, or with the Th2 cytokines IL-4 and IL-13, or the TFH associated factor Activin A. However, we did find an unexpected association between plasma IL-5 levels and bnAb development in these children. Importantly, although CXCL13 correlated with total circulating TFH cells, it was not associated with effector TFH. Additionally, raised CXCL13 expression was associated with a lower CD4 percentage, higher viral load and a loss of immune function, implying it is associated with progressive disease rather than HIV-specific GC activity in these subjects. Taken together, our data suggests that IL-5 should be evaluated further as a candidate plasma biomarker for HIV neutralization breadth and for monitoring vaccine responses in the pediatric age group. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10080275/1/Kloverpris_Plasma%20IL-5%20but%20not%20CXCL13%20correlates%20with%20neutralization%20breadth%20in%20HIV-infected%20children_VoR.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10080275Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10080275/1/Kloverpris_Plasma%20IL-5%20but%20not%20CXCL13%20correlates%20with%20neutralization%20breadth%20in%20HIV-infected%20children_VoR.pdfTest https://discovery.ucl.ac.uk/id/eprint/10080275Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.52024A4C |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |