التفاصيل البيبلوغرافية
| العنوان: |
Ustekinumab effectiveness in Crohn’s disease with lesions in the intestines |
| المؤلفون: |
Tamura, Satoshi, Asai, Yusuke, Ishida, Natsuki, Miyazu, Takahiro, Tani, Shinya, Yamade, Mihoko, Hamaya, Yasushi, Iwaizumi, Moriya, Osawa, Satoshi, Furuta, Takahisa, Sugimoto, Ken |
| المصدر: |
Medicine ; volume 103, issue 15, page e35647 ; ISSN 0025-7974 1536-5964 |
| بيانات النشر: |
Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: |
2024 |
| الوصف: |
Ustekinumab is prescribed for the treatment of patients with steroid-resistant moderate to severe Crohn’s disease. We investigated its clinical outcome in patients with small and large intestinal lesions. Patients who were newly administered ustekinumab between March 2014 and December 2020 at Hamamatsu University Hospital were included in the study. The primary endpoint was Crohn’s disease activity index score at baseline and weeks 8, 24, and 48 after the initiation of treatment, and secondary endpoints were albumin, hemoglobin, and C-reactive protein at these time points. Ustekinumab treatment retention was examined in both groups; the 2 groups were compared using the Friedman test, Mann–Whitney U test, or Fisher exact test. Overall, Crohn’s disease activity index scores improved between baseline and 48 weeks, but the difference was not significant. However, there was a significant improvement between baseline and 48 weeks in patients with lesions in the small intestine only. Overall, patients showed significant improvement in albumin levels between baseline and 48 weeks but not in C-reactive protein or hemoglobin levels. When limited to patients with lesions in the small intestine, albumin and hemoglobin levels showed significant improvement. Both types showed high rates of treatment retention, although there was no significant difference. Ustekinumab appears to be a safe and effective treatment option that may be particularly effective in patients with lesions in the small intestine only. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1097/md.0000000000035647 |
| DOI: |
10.1097/MD.0000000000035647 |
| الإتاحة: |
https://doi.org/10.1097/md.0000000000035647Test |
| حقوق: |
http://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: |
edsbas.51DBF5B3 |
| قاعدة البيانات: |
BASE |
