دورية أكاديمية
The genetic architecture of depression in individuals of East Asian ancestry : a genome-wide association study
| العنوان: | The genetic architecture of depression in individuals of East Asian ancestry : a genome-wide association study |
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| المؤلفون: | Giannakopoulou, Olga, Kuchenbaecker, Karoline, Domschke, Katharina, 23andMe Research Team, Study group, China Kadoorie Biobank Collaborative Group, Study group, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Study group |
| المصدر: | JAMA psychiatry. - 78, 11 (2021) , 1258, ISSN: 2168-622X |
| سنة النشر: | 2021 |
| المجموعة: | University of Freiburg: FreiDok |
| الوصف: | Importance: Most previous genome-wide association studies (GWAS) of depression have used data from individuals of European descent. This limits the understanding of the underlying biology of depression and raises questions about the transferability of findings between populations. Objective: To investigate the genetics of depression among individuals of East Asian and European descent living in different geographic locations, and with different outcome definitions for depression. Design, Setting, and Participants: Genome-wide association analyses followed by meta-analysis, which included data from 9 cohort and case-control data sets comprising individuals with depression and control individuals of East Asian descent. This study was conducted between January 2019 and May 2021. Exposures: Associations of genetic variants with depression risk were assessed using generalized linear mixed models and logistic regression. The results were combined across studies using fixed-effects meta-analyses. These were subsequently also meta-analyzed with the largest published GWAS for depression among individuals of European descent. Additional meta-analyses were carried out separately by outcome definition (clinical depression vs symptom-based depression) and region (East Asian countries vs Western countries) for East Asian ancestry cohorts. Main Outcomes and Measures: Depression status was defined based on health records and self-report questionnaires. Results: There were a total of 194 548 study participants (approximate mean age, 51.3 years; 62.8% women). Participants included 15 771 individuals with depression and 178 777 control individuals of East Asian descent. Five novel associations were identified, including 1 in the meta-analysis for broad depression among those of East Asian descent: rs4656484 (β = −0.018, SE = 0.003, P = 4.43x10−8) at 1q24.1. Another locus at 7p21.2 was associated in a meta-analysis restricted to geographically East Asian studies (β = 0.028, SE = 0.005, P = 6.48x10−9 for rs10240457). The lead ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | |
| اللغة: | English |
| العلاقة: | https://freidok.uni-freiburg.de/data/224274Test |
| DOI: | 10.1001/jamapsychiatry.2021.2099 |
| الإتاحة: | https://doi.org/10.1001/jamapsychiatry.2021.2099Test https://freidok.uni-freiburg.de/data/224274Test https://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-2242747Test https://freidok.uni-freiburg.de/dnb/download/224274Test |
| حقوق: | free |
| رقم الانضمام: | edsbas.51D51460 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1001/jamapsychiatry.2021.2099 |
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