التفاصيل البيبلوغرافية
| العنوان: |
A Bowman‐Birk trypsin inhibitor with antiproliferative activity from Hokkaido large black soybeans |
| المؤلفون: |
Ho, Vincent S. M., NG, T. B. |
| المصدر: |
Journal of Peptide Science ; volume 14, issue 3, page 278-282 ; ISSN 1075-2617 1099-1387 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2007 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
A trypsin inhibitor, with an N ‐terminal sequence highly homologous to those of 8‐kDa Bowman‐Birk trypsin inhibitors, was isolated from the seeds of Hokkaido large black soybeans. The trypsin inhibitor was unadsorbed on SP‐Sepharose but adsorbed on DEAE‐cellulose and Mono Q. It inhibited proliferation in breast cancer (MCF‐7) cells and hepatoma (Hep G2) cells with an IC 50 of 35 and 140 µ M , respectively. The trypsin inhibitory activity of the inhibitor was completely preserved after exposure to temperatures up to 100 °C for 30 min and to the pH range 2–13 for the same duration. The trypsin inhibitor inhibited HIV‐1 reverse transcriptase with an IC 50 of 38 µ M , but was devoid of antifungal activity toward Fusarium oxysporum and Mycosphaerella arachidicola . Copyright © 2007 European Peptide Society and John Wiley & Sons, Ltd. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/psc.922 |
| الإتاحة: |
https://doi.org/10.1002/psc.922Test |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.5179BEFE |
| قاعدة البيانات: |
BASE |
