دورية أكاديمية
Rv2617c and P36 are virulence factors of pathogenic mycobacteria involved in resistance to oxidative stress
| العنوان: | Rv2617c and P36 are virulence factors of pathogenic mycobacteria involved in resistance to oxidative stress |
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| المؤلفون: | Forrellad, Marina A., Vázquez, Cristina L., Blanco, Federico C., Klepp, Laura Inés, García, Elizabeth A., Rocha, Rosana V., Villafañe, Luciana, Bigi, María Mercedes |
| المصدر: | Virulence ; Vol.10, no.1 ; 1026–1033 ; https://taylorandfrancis.comTest |
| سنة النشر: | 2019 |
| المجموعة: | FAUBA Digital (Facultad de Agronomía, Universidad de Buenos Aires - UBA) |
| مصطلحات موضوعية: | MYCOBACTERIUM TUBERCULOSIS, OXIDATIVE STRESS, VIRULENCE FACTOR, RV2617C, ERP |
| الوصف: | Fil: Forrellad, Marina A. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología. Hurlingham, Buenos Aires, Argentina. ; Fil: Vázquez, Cristina L. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología. Hurlingham, Buenos Aires, Argentina. ; Fil: Blanco, Federico C. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología. Hurlingham, Buenos Aires, Argentina. ; Fil: Klepp, Laura Inés. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología. Hurlingham, Buenos Aires, Argentina. ; Fil: García, Elizabeth A. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología. Hurlingham, Buenos Aires, Argentina. ; Fil: Rocha, Rosana V. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología. Hurlingham, Buenos Aires, Argentina. ; Fil: Villafañe, Luciana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Biotecnología. Hurlingham, Buenos Aires, Argentina. ; Fil: Bigi, María Mercedes. Universidad de Buenos Aires. Facultad de Agronomía. Buenos Aires, Argentina. ; In this study, we characterized the role of Rv2617c in the virulence of Mycobacterium tuberculosis. Rv2617c is a protein of unknown function unique to M. tuberculosis complex (MTC) and Mycobacterium leprae. In vitro, this protein interacts with the virulence factor P36 (also named Erp) and KdpF, a protein linked to nitrosative stress. Here, we showed that knockout of the Rv2617c gene in M. tuberculosis CDC1551 reduced the replication of the pathogen in a mouse model of infection and favored the trafficking of mycobacteria to phagolysosomes. We also demonstrated that Rv2617c and P36 are required for resistance to in vitro hydrogen peroxide treatment in M. tuberculosis and Mycobacterium bovis, respectively. These findings indicate Rv2617c and P36 act in concert to prevent bacterial damage upon oxidative stress. ; grafs., fot. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2150-5608 |
| العلاقة: | http://ri.agro.uba.ar/greenstone3/library/collection/arti/document/2019forrelladTest |
| DOI: | 10.1080/21505594.2019.1693714 |
| الإتاحة: | https://doi.org/10.1080/21505594.2019.1693714Test http://ri.agro.uba.ar/greenstone3/library/collection/arti/document/2019forrelladTest |
| حقوق: | info:eu-repo/semantics/openAccess ; openAccess ; http://ri.agro.uba.ar/greenstone3/library/page/biblioteca#section4Test |
| رقم الانضمام: | edsbas.51454EAC |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 21505608 |
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| DOI: | 10.1080/21505594.2019.1693714 |