دورية أكاديمية
Antimicrobial efficacy of chlorine agents against selected oral pathogens
| العنوان: | Antimicrobial efficacy of chlorine agents against selected oral pathogens |
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| المؤلفون: | Almhöjd, Ulrica Scherdin, Lehrkinder, Anna, Roos‐Jansåker, Ann‐Marie, Lingström, Peter |
| بيانات النشر: | Malmö universitet, Odontologiska fakulteten (OD) Univ Gothenburg, Inst Odontol, Sahlgrenska Acad, Dept Cariol, Box 450, SE-40530 Gothenburg, Sweden. |
| سنة النشر: | 2023 |
| المجموعة: | Malmö University Electronic Publishing (MUEP) |
| مصطلحات موضوعية: | Chlorhexidine, Chlorine compounds, Dakin's, Dental caries, Oral disease, Periodontitis, Dentistry, Odontologi |
| الوصف: | Objectives: Method-dependent comparison of antimicrobial agents' efficacy against oral pathogens. Materials and methods: Several sodium hypochlorite solutions (NaOCl)-Perisolv®, Carisolv® and Dakin's solution-were equated with chlorhexidine (CHX) and hydrogen peroxide (H2O2) against ten oral micro-organisms related to caries and periodontitis using different minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) techniques. Agents were adjusted to the final 70 mmol/L concentration of active chlorine molecule. Results: Apart from H2O2 and the amino acids of Perisolv®, all the agents revealed an antimicrobial effect. Agar diffusion test ranked CHX (p < 0.05) as the most effective against all ten specimens, followed by the NaOCl of Perisolv® and Dakin's solution. Correspondingly, in broth microdilution on agar, CHX was the most effective in eradicating micro-organisms at 0.03 mmol/L compared with 2.2 mmol/L of Dakin's solution. In contrast, the bactericidal concentration of Dakin's solution was the most effective at 0.2 mmol/L, (p < 0.001), followed by Perisolv® (2.14 mmol/L), CHX (2.38 mmol/L) and Carisolv® (3.33 mmol/L) after 5 and 10 min in broth dilution test. In live/dead analysis, 60-min exposure to a 2-fold concentration of agents resulted in two-log Aggregatibacter actinomycetemcomitans inhibition by CHX (35 mmol/L) whilst Streptococcus mutans was more susceptible, in 0.8 and 8.8 mmol/L, after 10 min to CHX and Dakin's respectively. Conclusion: Replacement of CHX with tested hypochlorite agents showed evident potential and promoted rapid antimicrobial effect. Clinical relevance: Effective antimicrobial agents are crucial in controlling pathogen-induced oral infections increasing clinical possibilities to combat oral biofilms. Additionally, CHX substitution with hypochlorite agents could eliminate CHX's adverse effects. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Clinical Oral Investigations, 1432-6981, 2023, 27:9, s. 5695-5707; http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-62585Test; PMID 37606720; ISI:001052774000004; Scopus 2-s2.0-85168610021 |
| DOI: | 10.1007/s00784-023-05190-0 |
| الإتاحة: | https://doi.org/10.1007/s00784-023-05190-0Test http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-62585Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.5131C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00784-023-05190-0 |
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