دورية أكاديمية
Prior infection by seasonal coronaviruses, as assessed by serology, does not prevent SARS-CoV-2 infection and disease in children, France, April to June 2020
| العنوان: | Prior infection by seasonal coronaviruses, as assessed by serology, does not prevent SARS-CoV-2 infection and disease in children, France, April to June 2020 |
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| المؤلفون: | Sermet-Gaudelus, Isabelle, Temmam, Sarah, Huon, Christèle, Behillil, Sylvie, Gajdos, Vincent, Bigot, Thomas, Lurier, Thibaut, Chrétien, Delphine, Backovic, Marija, Delaunay-Moisan, Agnès, Donati, Flora, Albert, Mélanie, Foucaud, Elsa, Mesplées, Bettina, Benoist, Grégoire, Faye, Albert, Duval-Arnould, Marc, Cretolle, Célia, Charbit, Marina, Aubart, Mélodie, Auriau, Johanne, Lorrot, Mathie, Kariyawasam, Dulanjalee, Fertitta, Laura, Orliaguet, Gilles, Pigneur, Bénédicte, Bader-Meunier, Brigitte, Briand, Coralie, Enouf, Vincent, Toubiana, Julie, Guilleminot, Tiffany, van Der Werf, Sylvie, Leruez-Ville, Marianne, Eloit, Marc |
| المساهمون: | Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), UFR Médecine Santé - Université Paris Cité (UFR Médecine UPCité), Université Paris Cité (UPCité), Hôpital Necker - Enfants Malades AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Découverte de pathogènes – Pathogen discovery, Institut Pasteur Paris (IP), Centre National de Référence des virus des infections respiratoires (dont la grippe) - National Reference Center Virus Influenzae Paris (CNR - laboratoire coordonnateur), Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses (GMV-ARN (UMR_3569 / U-Pasteur_2)), Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), AP-HP - Hôpital Antoine Béclère Clamart, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche d'Épidémiologie des maladies Animales et zoonotiques (UMR EPIA), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Rongeurs Sauvages, Risques Sanitaires et Gestion des Populations - UR 1233 (RS2GP), Virologie Structurale - Structural Virology, Département Plateforme (PF I2BC), Institut de Biologie Intégrative de la Cellule (I2BC), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Hôpital Jean Verdier AP-HP, Hôpital Louis Mourier - AP-HP Colombes, Hôpital Ambroise Paré AP-HP, Hôpital Robert Debré Paris, Hôpital Robert Debré, Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre, CHU Trousseau APHP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Plateforme de Microbiologie Mutualisée (PIBnet) - Mutualized Platform for Microbiology (P2M), Pasteur International Bioresources network (PIBNet), Biodiversité et Epidémiologie des Bactéries pathogènes - Biodiversity and Epidemiology of Bacterial Pathogens, Laboratoire de Microbiologie Clinique AP-HP Hôpital Necker-Enfants Malades, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), École nationale vétérinaire d'Alfort (ENVA), This work was supported by the « URGENCE COVID-19 » fundraising campaign of Institut Pasteur., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010) |
| المصدر: | ISSN: 1560-7917. |
| بيانات النشر: | HAL CCSD European Centre for Disease Prevention and Control |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 229E, COVID-19, HKU1, NL63, OC43, SARS-CoV-2, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Background Children have a low rate of COVID-19 and secondary severe multisystem inflammatory syndrome (MIS) but present a high prevalence of symptomatic seasonal coronavirus infections. Aim We tested if prior infections by seasonal coronaviruses (HCoV) NL63, HKU1, 229E or OC43 as assessed by serology, provide cross-protective immunity against SARS-CoV-2 infection. Methods We set a cross-sectional observational multicentric study in pauci- or asymptomatic children hospitalised in Paris during the first wave for reasons other than COVID (hospitalised children (HOS), n = 739) plus children presenting with MIS (n = 36). SARS-CoV-2 antibodies directed against the nucleoprotein (N) and S1 and S2 domains of the spike (S) proteins were monitored by an in-house luciferase immunoprecipitation system assay. We randomly selected 69 SARS-CoV-2-seropositive patients (including 15 with MIS) and 115 matched SARS-CoV-2-seronegative patients (controls (CTL)). We measured antibodies against SARS-CoV-2 and HCoV as evidence for prior corresponding infections and assessed if SARS-CoV-2 prevalence of infection and levels of antibody responses were shaped by prior seasonal coronavirus infections. Results Prevalence of HCoV infections were similar in HOS, MIS and CTL groups. Antibody levels against HCoV were not significantly different in the three groups and were not related to the level of SARS-CoV-2 antibodies in the HOS and MIS groups. SARS-CoV-2 antibody profiles were different between HOS and MIS children. Conclusion Prior infection by seasonal coronaviruses, as assessed by serology, does not interfere with SARS-CoV-2 infection and related MIS in children. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| ردمك: | 978-0-00-638228-7 0-00-638228-2 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33797390; hal-03205795; https://hal.inrae.fr/hal-03205795Test; https://hal.inrae.fr/hal-03205795/documentTest; https://hal.inrae.fr/hal-03205795/file/eurosurv-26-13-2.pdfTest; PUBMED: 33797390; PUBMEDCENTRAL: PMC8017906; WOS: 000638228200002 |
| DOI: | 10.2807/1560-7917.ES.2021.26.13.2001782 |
| الإتاحة: | https://doi.org/10.2807/1560-7917.ES.2021.26.13.2001782Test https://hal.inrae.fr/hal-03205795Test https://hal.inrae.fr/hal-03205795/documentTest https://hal.inrae.fr/hal-03205795/file/eurosurv-26-13-2.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.5115ADD5 |
| قاعدة البيانات: | BASE |
| ردمك: | 9780006382287 0006382282 |
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| DOI: | 10.2807/1560-7917.ES.2021.26.13.2001782 |