دورية أكاديمية
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Impaired angiogenesis, delayed wound healing and retarded tumor growth in Perlecan heparan sulfate-deficient mice

التفاصيل البيبلوغرافية
العنوان: Impaired angiogenesis, delayed wound healing and retarded tumor growth in Perlecan heparan sulfate-deficient mice
المؤلفون: Cao, R, Wang, J, Morita, H, Soininen, R, Chan, KM, Cao, Y, Zhou, Z, Liu, B, Tryggvason, K
بيانات النشر: //cancerres.aacrjournals.org/
United States
سنة النشر: 2004
المجموعة: University of Hong Kong: HKU Scholars Hub
مصطلحات موضوعية: Transfection, Neovascularization, Pathologic - pathology, Neoplasms, Experimental - blood supply - genetics - pathology, NIH 3T3 Cells, Mice, Inbred C57BL, Male, Heparan Sulfate Proteoglycans - deficiency - genetics, Blood Vessels - pathology, Cell Division - physiology, Cornea - blood supply, Female, Fibroblast Growth Factor 2 - genetics - physiology, Animals, Basement Membrane - pathology, Wound Healing - physiology, Physiologic - physiology
الوصف: Perlecan, a modular proteoglycan carrying primary heparan sulfate (HS) side chains, is a major component of blood vessel basement membranes. It sequesters growth factors such as fibroblast growth factor 2 (FGF-2) and regulates the ligand-receptor interactions on the cell surface, and thus it has been implicated in the control of angiogenesis. Both stimulatory and inhibitory effects of perlecan on FGF-2 signaling have been reported. To understand the in vivo function of HS carried by perlecan, the perlecan gene heparan sulfate proteoglycan 2 (Hspg2) was mutated in mouse by gene targeting. The HS at the NH2 terminus of perlecan was removed while the core protein remained intact. Perlecan HS-deficient (Hspg2Δ3/Δ3) mice survived embryonic development and were apparently healthy as adults. However, mutant mice exhibited significantly delayed wound healing, retarded FGF-2-induced tumor growth, and defective angiogenesis. In the mouse corneal angiogenesis model, FGF-2-induced neovascularization was significantly impaired in Hspg2 Δ3/Δ3 mutant mice. Our results suggest that HS in perlecan positively regulates the angiogenesis in vivo. ; link_to_subscribed_fulltext
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 0008-5472
العلاقة: Cancer Research; http://www.scopus.com/mlt/select.url?eid=2-s2.0-3142682314&selection=ref&src=s&origin=recordpageTest; Cancer Research, 2004, v. 64 n. 14, p. 4699-4702; 4702; 95437; WOS:000222674700003; 14; eid_2-s2.0-3142682314; 4699; http://hdl.handle.net/10722/134122Test; 64
DOI: 10.1158/0008-5472.CAN-04-0810
الإتاحة: https://doi.org/10.1158/0008-5472.CAN-04-0810Test
http://hdl.handle.net/10722/134122Test
رقم الانضمام: edsbas.50869AD0
قاعدة البيانات: BASE
الوصف
تدمد:00085472
DOI:10.1158/0008-5472.CAN-04-0810